Detailed information of TA system TA227152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 121662..122209
• Replicon: chromosome
• Accession: NZ_CP088935
• Organism: Thauera sp. WB-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LQF09_RS00510
• Protein ID: WP_270068878.1
• Coordinates: 121931..122209 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LQF09_RS00505
• Protein ID: WP_270068877.1
• Coordinates: 121662..121931 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF09_RS00485 (LQF09_00480)	117579..118184	+	606	WP_270068873.1	exopolysaccharide biosynthesis protein	-
LQF09_RS00490 (LQF09_00485)	118559..119161	+	603	WP_270068874.1	NAD(P)H:quinone oxidoreductase	-
LQF09_RS00495 (LQF09_00490)	119663..120235	+	573	WP_270068875.1	hypothetical protein	-
LQF09_RS00500 (LQF09_00495)	120232..121422	+	1191	WP_270068876.1	hypothetical protein	-
LQF09_RS00505 (LQF09_00500)	121662..121931	+	270	WP_270068877.1	ribbon-helix-helix domain-containing protein	Antitoxin
LQF09_RS00510 (LQF09_00505)	121931..122209	+	279	WP_270068878.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LQF09_RS00515 (LQF09_00510)	122213..123667	+	1455	WP_270068879.1	DUF3375 domain-containing protein	-
LQF09_RS00520 (LQF09_00515)	123691..124359	+	669	WP_270068880.1	DUF4194 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	67886..131135	63249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10772.56 Da
• Isoelectric Point: 10.6100

>T227152 WP_270068878.1 NZ_CP088935:121931-122209 [Thauera sp. WB-2]
MELKWTSKALADLVRLHEFLAPVNRQAAAKTVQGLTKAPTILLSNPRIGEQLFQFAPREVRRILVAQYEVRYEIRDSVIY
VLRLWHTREDRA

Nucleotide

• Length: 279 bp

>T227152 NZ_CP122727:2016783-2016886 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9801.23 Da
• Isoelectric Point: 4.5388

>AT227152 WP_270068877.1 NZ_CP088935:121662-121931 [Thauera sp. WB-2]
MTQATTKVLTAHVPLPLAEKVDQMAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVDAGLVVDPLAVQAWADSLG
TDQPLPLPR

Nucleotide

• Length: 270 bp

>AT227152 NZ_CP122727:c2016924-2016653 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT