Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1725372..1726002 Replicon chromosome
Accession NZ_CP088923
Organism Rhodanobacter thiooxydans strain FW510-R12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRK53_RS07735 Protein ID WP_027493003.1
Coordinates 1725592..1726002 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRK53_RS07730 Protein ID WP_027493004.1
Coordinates 1725372..1725602 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK53_RS07710 (LRK53_07710) 1721453..1721755 + 303 WP_027493008.1 hypothetical protein -
LRK53_RS07715 (LRK53_07715) 1722213..1722476 - 264 WP_027493007.1 30S ribosomal protein S20 -
LRK53_RS07720 (LRK53_07720) 1722697..1724307 + 1611 WP_037089850.1 murein biosynthesis integral membrane protein MurJ -
LRK53_RS07725 (LRK53_07725) 1724338..1725291 + 954 WP_027493005.1 bifunctional riboflavin kinase/FAD synthetase -
LRK53_RS07730 (LRK53_07730) 1725372..1725602 + 231 WP_027493004.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LRK53_RS07735 (LRK53_07735) 1725592..1726002 + 411 WP_027493003.1 PIN domain-containing protein Toxin
LRK53_RS07740 (LRK53_07740) 1726096..1729086 + 2991 WP_027493002.1 isoleucine--tRNA ligase -
LRK53_RS07745 (LRK53_07745) 1729229..1729729 + 501 WP_027493001.1 signal peptidase II -
LRK53_RS07750 (LRK53_07750) 1729846..1730808 + 963 WP_027493000.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

SpoVT-AbrB domain

(5-40)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14529.64 Da        Isoelectric Point: 5.7079

>T227145 WP_027493003.1 NZ_CP088923:1725592-1726002 [Rhodanobacter thiooxydans]
MSAKAFIDSNIVLYLLSADTGKADRAEAVIAAGGVVSVQVLNEVTSVARRKLGMSWSETAEVLAGLRAVCPVESLTADTH
DTGRRLAERYGLSVYDAMIASSALLAGCNRLYSEDMQHGLLIDRQLRVCNPFIGPS

Download         Length: 411 bp

>T227145 NZ_CP122727:c645541-645077 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8626.95 Da        Isoelectric Point: 11.0713

>AT227145 WP_027493004.1 NZ_CP088923:1725372-1725602 [Rhodanobacter thiooxydans]
MQVSKWGNSLAIRLPAAVVDALQLRDGDDIEVRVAGARVFEVKKEPGRQELLQRLRKFRGRLPAGFVFERDGAHER

Download         Length: 231 bp

>AT227145 NZ_CP122727:c645876-645541 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References