Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HTH_37(antitoxin)
Location 1238812..1239440 Replicon chromosome
Accession NZ_CP088921
Organism Rhodanobacter denitrificans strain FW104-R3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LRK44_RS05630 Protein ID WP_007513282.1
Coordinates 1238812..1238988 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LRK44_RS05635 Protein ID WP_007513280.1
Coordinates 1239021..1239440 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK44_RS05615 (LRK44_05615) 1233885..1236008 - 2124 WP_027489900.1 M13-type metalloendopeptidase -
LRK44_RS05620 (LRK44_05620) 1236127..1237959 - 1833 WP_037115014.1 M14 family metallopeptidase -
LRK44_RS05625 (LRK44_05625) 1237956..1238633 - 678 WP_037115012.1 DUF502 domain-containing protein -
LRK44_RS05630 (LRK44_05630) 1238812..1238988 + 177 WP_007513282.1 type II toxin-antitoxin system HicA family toxin Toxin
LRK44_RS05635 (LRK44_05635) 1239021..1239440 + 420 WP_007513280.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LRK44_RS05640 (LRK44_05640) 1240205..1241824 - 1620 WP_027489898.1 type I restriction-modification system subunit M -
LRK44_RS05645 (LRK44_05645) 1241831..1242991 - 1161 WP_231378343.1 AAA family ATPase -
LRK44_RS05650 (LRK44_05650) 1242988..1243998 - 1011 WP_027489896.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6834.93 Da        Isoelectric Point: 11.0888

>T227136 WP_007513282.1 NZ_CP088921:1238812-1238988 [Rhodanobacter denitrificans]
MKYSEFQRWLRQQGVSFEPGKGSHQLARYRGRTSVFPFHGSKEMPEPLRKKILKDLGL

Download         Length: 177 bp

>T227136 NZ_CP122722:c4495404-4495117 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15470.93 Da        Isoelectric Point: 8.0203

>AT227136 WP_007513280.1 NZ_CP088921:1239021-1239440 [Rhodanobacter denitrificans]
MKYPVKLTRADSVVMVTCPDLPEFSSVGDTEGEALREAVDGIETTLQAYMQDRRDIPPPGARKRGQRLVELPPLAVAKLG
LYRAMREQGLRKADLARRLDVHLPQVDRLLDLRHSSKLEQVEAALNALGYRIELAVLAA

Download         Length: 420 bp

>AT227136 NZ_CP122722:c4495130-4494828 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References