Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HTH_37(antitoxin)
Location 1238817..1239445 Replicon chromosome
Accession NZ_CP088920
Organism Rhodanobacter denitrificans strain FW104-10F02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LRK32_RS05625 Protein ID WP_007513282.1
Coordinates 1238817..1238993 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LRK32_RS05630 Protein ID WP_007513280.1
Coordinates 1239026..1239445 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK32_RS05610 (LRK32_05610) 1233890..1236013 - 2124 WP_027489900.1 M13-type metalloendopeptidase -
LRK32_RS05615 (LRK32_05615) 1236132..1237964 - 1833 WP_037115014.1 M14 family metallopeptidase -
LRK32_RS05620 (LRK32_05620) 1237961..1238638 - 678 WP_037115012.1 DUF502 domain-containing protein -
LRK32_RS05625 (LRK32_05625) 1238817..1238993 + 177 WP_007513282.1 type II toxin-antitoxin system HicA family toxin Toxin
LRK32_RS05630 (LRK32_05630) 1239026..1239445 + 420 WP_007513280.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LRK32_RS05635 (LRK32_05635) 1240210..1241829 - 1620 WP_027489898.1 type I restriction-modification system subunit M -
LRK32_RS05640 (LRK32_05640) 1241836..1242996 - 1161 WP_231378343.1 AAA family ATPase -
LRK32_RS05645 (LRK32_05645) 1242993..1244003 - 1011 WP_027489896.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6834.93 Da        Isoelectric Point: 11.0888

>T227132 WP_007513282.1 NZ_CP088920:1238817-1238993 [Rhodanobacter denitrificans]
MKYSEFQRWLRQQGVSFEPGKGSHQLARYRGRTSVFPFHGSKEMPEPLRKKILKDLGL

Download         Length: 177 bp

>T227132 NZ_CP122722:c2631480-2631193 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15470.93 Da        Isoelectric Point: 8.0203

>AT227132 WP_007513280.1 NZ_CP088920:1239026-1239445 [Rhodanobacter denitrificans]
MKYPVKLTRADSVVMVTCPDLPEFSSVGDTEGEALREAVDGIETTLQAYMQDRRDIPPPGARKRGQRLVELPPLAVAKLG
LYRAMREQGLRKADLARRLDVHLPQVDRLLDLRHSSKLEQVEAALNALGYRIELAVLAA

Download         Length: 420 bp

>AT227132 NZ_CP122722:c2631719-2631480 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References