Detailed information of TA system TA022712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1523285..1523703
• Replicon: chromosome
• Accession: NC_010483
• Organism: Thermotoga sp. RQ2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: TRQ2_RS07825
• Protein ID: WP_012311169.1
• Coordinates: 1523500..1523703 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: Q9X145
• Locus tag: TRQ2_RS07820
• Protein ID: WP_004083352.1
• Coordinates: 1523285..1523503 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRQ2_RS07810	1519556..1520947	-	1392	WP_004083362.1	radical SAM protein	-
TRQ2_RS09780	1521049..1521144	-	96	WP_010865309.1	Cys-rich RiPP peptide	-
TRQ2_RS09785	1521221..1521385	-	165	WP_004083364.1	hypothetical protein	-
TRQ2_RS07815	1521581..1523188	+	1608	WP_012311168.1	helix-turn-helix domain-containing protein	-
TRQ2_RS07820	1523285..1523503	+	219	WP_004083352.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TRQ2_RS07825	1523500..1523703	+	204	WP_012311169.1	type II toxin-antitoxin system HicA family toxin	Toxin
TRQ2_RS09660	1523937..1524333	-	397	Protein_1516	ABC transporter ATP-binding protein	-
TRQ2_RS09795	1524397..1525167	-	771	Protein_1517	ABC transporter permease	-
TRQ2_RS07840	1525171..1525605	-	435	WP_041434362.1	ABC transporter permease	-
TRQ2_RS07845	1525823..1526629	-	807	WP_004079915.1	ABC transporter permease	-
TRQ2_RS07850	1526623..1527384	-	762	WP_004079916.1	ABC transporter permease	-
TRQ2_RS07855	1527335..1528111	-	777	WP_004079917.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1521221..1529539	8318

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-57)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7911.60 Da
• Isoelectric Point: 12.1872

>T22712 WP_012311169.1 NC_010483:1523500-1523703 [Thermotoga sp. RQ2]
MSRLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGKYTTIPFHARALPKSLIRKIIRSIFMFIL

Nucleotide

• Length: 204 bp

>T22712 NC_010483:1523500-1523703 [Thermotoga sp. RQ2]
TTGAGTCGTCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGAAAGTATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTAGTATATTCATGTTCATTTTGTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8183.29 Da
• Isoelectric Point: 4.0887

>AT22712 WP_004083352.1 NC_010483:1523285-1523503 [Thermotoga sp. RQ2]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Nucleotide

• Length: 219 bp

>AT22712 NC_010483:1523285-1523503 [Thermotoga sp. RQ2]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0A6N0B1