Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48630..49273 Replicon plasmid pESI
Accession NZ_CP088902
Organism Salmonella enterica subsp. enterica serovar Muenchen strain 180135033

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag LRP35_RS24015 Protein ID WP_023994137.1
Coordinates 48630..49046 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag LRP35_RS24020 Protein ID WP_023994136.1
Coordinates 49043..49273 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP35_RS23985 (LRP35_23990) 44110..44901 + 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -
LRP35_RS23990 (LRP35_23995) 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
LRP35_RS23995 (LRP35_24000) 45896..46486 + 591 WP_023994140.1 hypothetical protein -
LRP35_RS24000 (LRP35_24005) 46552..46764 + 213 WP_023994139.1 FaeA/PapI family transcriptional regulator -
LRP35_RS24005 (LRP35_24010) 47025..47186 + 162 WP_001816720.1 hypothetical protein -
LRP35_RS24010 (LRP35_24015) 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
LRP35_RS24015 (LRP35_24020) 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
LRP35_RS24020 (LRP35_24025) 49043..49273 - 231 WP_023994136.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRP35_RS24025 (LRP35_24030) 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
LRP35_RS24030 (LRP35_24035) 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
LRP35_RS24035 (LRP35_24040) 50424..50714 + 291 WP_023994133.1 hypothetical protein -
LRP35_RS25195 50711..50986 + 276 Protein_59 3'-5' exonuclease -
LRP35_RS24050 (LRP35_24055) 51057..51173 + 117 Protein_60 hypothetical protein -
LRP35_RS24055 (LRP35_24060) 51163..51878 - 716 Protein_61 transposase -
LRP35_RS24060 (LRP35_24065) 53160..53696 + 537 WP_023994130.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) / dfrA14 faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..285167 285167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15123.58 Da        Isoelectric Point: 8.5291

>T227118 WP_023994137.1 NZ_CP088902:c49046-48630 [Salmonella enterica subsp. enterica serovar Muenchen]
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR

Download         Length: 417 bp

>T227118 NZ_CP122722:c621894-621430 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8650.75 Da        Isoelectric Point: 4.5881

>AT227118 WP_023994136.1 NZ_CP088902:c49273-49043 [Salmonella enterica subsp. enterica serovar Muenchen]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT227118 NZ_CP122722:c622229-621894 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References