Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4165441..4166133 | Replicon | chromosome |
| Accession | NZ_CP088901 | ||
| Organism | Salmonella enterica subsp. enterica serovar Muenchen strain 180135033 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A737B651 |
| Locus tag | LRP35_RS20460 | Protein ID | WP_020437644.1 |
| Coordinates | 4165441..4165779 (-) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A737AZQ1 |
| Locus tag | LRP35_RS20465 | Protein ID | WP_031250916.1 |
| Coordinates | 4165804..4166133 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRP35_RS20440 (4161134) | 4161134..4161850 | + | 717 | WP_000532939.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
| LRP35_RS20445 (4162329) | 4162329..4163204 | - | 876 | WP_020437647.1 | HNH endonuclease | - |
| LRP35_RS20450 (4163553) | 4163553..4164350 | - | 798 | WP_020437646.1 | helix-turn-helix transcriptional regulator | - |
| LRP35_RS20455 (4164494) | 4164494..4165327 | - | 834 | WP_021294339.1 | DUF4942 domain-containing protein | - |
| LRP35_RS20460 (4165441) | 4165441..4165779 | - | 339 | WP_020437644.1 | TA system toxin CbtA family protein | Toxin |
| LRP35_RS20465 (4165804) | 4165804..4166133 | - | 330 | WP_031250916.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LRP35_RS20470 (4166157) | 4166157..4166636 | - | 480 | WP_023197794.1 | DNA repair protein RadC | - |
| LRP35_RS20475 (4166657) | 4166657..4166923 | - | 267 | WP_020437641.1 | hypothetical protein | - |
| LRP35_RS20480 (4167389) | 4167389..4168012 | + | 624 | WP_021294340.1 | inovirus Gp2 family protein | - |
| LRP35_RS20485 (4168131) | 4168131..4168346 | + | 216 | WP_020437639.1 | AlpA family transcriptional regulator | - |
| LRP35_RS20490 (4168891) | 4168891..4170582 | - | 1692 | WP_020437638.1 | YfjI family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4157586..4176065 | 18479 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 12783.72 Da Isoelectric Point: 8.5135
>T227112 WP_020437644.1 NZ_CP088901:c4165779-4165441 [Salmonella enterica subsp. enterica serovar Muenchen]
MKILSANQRVAKPCPPPVLVWQTLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQNQLPSTR
MKILSANQRVAKPCPPPVLVWQTLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQNQLPSTR
Download Length: 339 bp
>T227112 NZ_CP122719:4567930-4568307 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTTACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACGCCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATATCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACAAGCCGGGATTC
AACGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTGAACAATATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTTACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACGCCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATATCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACAAGCCGGGATTC
AACGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTGAACAATATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12431.03 Da Isoelectric Point: 6.3196
>AT227112 WP_031250916.1 NZ_CP088901:c4166133-4165804 [Salmonella enterica subsp. enterica serovar Muenchen]
MDKETDTVQWGLNRPGSPQFSARLVQEGKRLHYLADRAGITGAFNEEECHQLNAAFPHFVKQMELMLLSGELNPRHAYRV
TLYHNELTCEADTLGSCGYVYIAIYPTQR
MDKETDTVQWGLNRPGSPQFSARLVQEGKRLHYLADRAGITGAFNEEECHQLNAAFPHFVKQMELMLLSGELNPRHAYRV
TLYHNELTCEADTLGSCGYVYIAIYPTQR
Download Length: 330 bp
>AT227112 NZ_CP122719:4567472-4567840 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A737B651 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A737AZQ1 |