Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 737953..738628 | Replicon | chromosome |
| Accession | NC_010482 | ||
| Organism | Candidatus Korarchaeum cryptofilum OPF8 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | B1L4T7 |
| Locus tag | KCR_RS03710 | Protein ID | WP_012309363.1 |
| Coordinates | 737953..738363 (-) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B1L4T8 |
| Locus tag | KCR_RS03715 | Protein ID | WP_012309364.1 |
| Coordinates | 738347..738628 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KCR_RS03685 (Kcr_0711) | 734421..734963 | + | 543 | WP_187146654.1 | GNAT family N-acetyltransferase | - |
| KCR_RS03690 (Kcr_0712) | 735422..736210 | - | 789 | WP_012309359.1 | ATP-binding protein | - |
| KCR_RS03695 (Kcr_0713) | 736536..736802 | + | 267 | WP_012309360.1 | DUF433 domain-containing protein | - |
| KCR_RS03700 (Kcr_0714) | 736843..737097 | + | 255 | WP_187146655.1 | ribbon-helix-helix domain-containing protein | - |
| KCR_RS08610 | 737094..737276 | + | 183 | WP_148204009.1 | hypothetical protein | - |
| KCR_RS03705 (Kcr_0715) | 737352..737708 | - | 357 | WP_012309362.1 | aspartyl protease | - |
| KCR_RS03710 (Kcr_0716) | 737953..738363 | - | 411 | WP_012309363.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KCR_RS03715 (Kcr_0717) | 738347..738628 | - | 282 | WP_012309364.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| KCR_RS03720 (Kcr_0718) | 738866..739201 | + | 336 | WP_012309365.1 | HEPN domain-containing protein | - |
| KCR_RS03725 (Kcr_0719) | 739245..739640 | + | 396 | WP_012309366.1 | nucleotidyltransferase domain-containing protein | - |
| KCR_RS03730 (Kcr_0720) | 739883..740245 | - | 363 | WP_012309367.1 | hypothetical protein | - |
| KCR_RS03735 (Kcr_0721) | 740517..740816 | + | 300 | WP_052568174.1 | hypothetical protein | - |
| KCR_RS03740 (Kcr_0722) | 740803..741153 | + | 351 | WP_012309369.1 | hypothetical protein | - |
| KCR_RS03745 (Kcr_0723) | 741287..741688 | - | 402 | WP_012309370.1 | hypothetical protein | - |
| KCR_RS03750 (Kcr_0724) | 742489..742737 | + | 249 | WP_012309371.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 15767.19 Da Isoelectric Point: 4.5740
>T22711 WP_012309363.1 NC_010482:c738363-737953 [Candidatus Korarchaeum cryptofilum OPF8]
MKTFIDAPLLIYLNTVESRELRSSYENFYLDILVKYRAYTDILILDELIYVSRRKYGVPYELSIEFVRSVVLPYVTLLSI
GEEEYNYAVEAIKMGLRPSDAIHIGAMRSNGIKLIVSEDEDFDKVEGVKRIWIGSE
MKTFIDAPLLIYLNTVESRELRSSYENFYLDILVKYRAYTDILILDELIYVSRRKYGVPYELSIEFVRSVVLPYVTLLSI
GEEEYNYAVEAIKMGLRPSDAIHIGAMRSNGIKLIVSEDEDFDKVEGVKRIWIGSE
Download Length: 411 bp
>T22711 NC_010482:c738363-737953 [Candidatus Korarchaeum cryptofilum OPF8]
ATGAAGACATTTATTGATGCCCCCCTCCTGATCTACCTCAATACGGTGGAGAGCAGGGAGCTCAGATCCTCCTATGAGAA
CTTCTACTTGGATATCCTGGTCAAATATAGGGCTTATACAGATATTTTAATCTTAGATGAGCTGATTTACGTGAGCAGGA
GAAAATATGGCGTCCCATATGAGCTCTCAATAGAGTTCGTGAGGTCCGTAGTCCTACCTTATGTGACTCTGTTGAGCATA
GGGGAGGAGGAATATAACTATGCTGTAGAAGCGATTAAAATGGGCCTCAGGCCATCGGATGCGATACATATTGGGGCGAT
GAGGAGCAACGGAATAAAGCTGATTGTCAGTGAGGATGAGGATTTCGACAAAGTAGAGGGAGTGAAGAGGATCTGGATAG
GATCGGAATGA
ATGAAGACATTTATTGATGCCCCCCTCCTGATCTACCTCAATACGGTGGAGAGCAGGGAGCTCAGATCCTCCTATGAGAA
CTTCTACTTGGATATCCTGGTCAAATATAGGGCTTATACAGATATTTTAATCTTAGATGAGCTGATTTACGTGAGCAGGA
GAAAATATGGCGTCCCATATGAGCTCTCAATAGAGTTCGTGAGGTCCGTAGTCCTACCTTATGTGACTCTGTTGAGCATA
GGGGAGGAGGAATATAACTATGCTGTAGAAGCGATTAAAATGGGCCTCAGGCCATCGGATGCGATACATATTGGGGCGAT
GAGGAGCAACGGAATAAAGCTGATTGTCAGTGAGGATGAGGATTTCGACAAAGTAGAGGGAGTGAAGAGGATCTGGATAG
GATCGGAATGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10627.21 Da Isoelectric Point: 5.0278
>AT22711 WP_012309364.1 NC_010482:c738628-738347 [Candidatus Korarchaeum cryptofilum OPF8]
MTLRLKVGRKGYLILPKAIREAVGIEEGDEVLVEVGDGIILRPVKGRADADKLRDALRRHLENLKEIEGRKEPKPGELAR
SYLEEEFENEDIY
MTLRLKVGRKGYLILPKAIREAVGIEEGDEVLVEVGDGIILRPVKGRADADKLRDALRRHLENLKEIEGRKEPKPGELAR
SYLEEEFENEDIY
Download Length: 282 bp
>AT22711 NC_010482:c738628-738347 [Candidatus Korarchaeum cryptofilum OPF8]
TTGACTCTCCGCCTTAAGGTTGGGAGGAAGGGATATTTGATCCTCCCGAAGGCGATAAGGGAGGCTGTTGGCATAGAGGA
GGGGGATGAGGTGCTAGTTGAAGTCGGAGATGGAATAATCCTCAGACCTGTGAAGGGCAGAGCCGATGCCGATAAACTCA
GGGATGCCCTCAGGAGACATCTAGAAAATCTGAAGGAGATAGAGGGAAGGAAGGAACCGAAACCAGGTGAGCTAGCGAGG
TCATATCTGGAGGAGGAGTTCGAGAATGAAGACATTTATTGA
TTGACTCTCCGCCTTAAGGTTGGGAGGAAGGGATATTTGATCCTCCCGAAGGCGATAAGGGAGGCTGTTGGCATAGAGGA
GGGGGATGAGGTGCTAGTTGAAGTCGGAGATGGAATAATCCTCAGACCTGTGAAGGGCAGAGCCGATGCCGATAAACTCA
GGGATGCCCTCAGGAGACATCTAGAAAATCTGAAGGAGATAGAGGGAAGGAAGGAACCGAAACCAGGTGAGCTAGCGAGG
TCATATCTGGAGGAGGAGTTCGAGAATGAAGACATTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|