Detailed information of TA system TA227108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3521477..3522097
• Replicon: chromosome
• Accession: NZ_CP088901
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain 180135033

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LRP35_RS17475
• Protein ID: WP_001280991.1
• Coordinates: 3521879..3522097 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LRP35_RS17470
• Protein ID: WP_000344807.1
• Coordinates: 3521477..3521851 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRP35_RS17460 (3516616)	3516616..3517809	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LRP35_RS17465 (3517832)	3517832..3520981	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LRP35_RS17470 (3521477)	3521477..3521851	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LRP35_RS17475 (3521879)	3521879..3522097	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LRP35_RS17480 (3522276)	3522276..3522827	+	552	WP_001278792.1	maltose O-acetyltransferase	-
LRP35_RS17485 (3522944)	3522944..3523414	+	471	WP_000136181.1	YlaC family protein	-
LRP35_RS17490 (3523470)	3523470..3523610	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LRP35_RS17495 (3523616)	3523616..3523876	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LRP35_RS17500 (3524101)	3524101..3525651	+	1551	WP_000213140.1	EAL domain-containing protein	-
LRP35_RS17510 (3525882)	3525882..3526271	+	390	WP_000961285.1	MGMT family protein	-
LRP35_RS17515 (3526304)	3526304..3526873	-	570	WP_020437370.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T227108 WP_001280991.1 NZ_CP088901:3521879-3522097 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T227108 NZ_CP122719:3772514-3772732 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT227108 WP_000344807.1 NZ_CP088901:3521477-3521851 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT227108 NZ_CP122719:3772114-3772488 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0