Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1017320..1018134 Replicon chromosome
Accession NZ_CP088901
Organism Salmonella enterica subsp. enterica serovar Muenchen strain 180135033

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LRP35_RS04900 Protein ID WP_000971655.1
Coordinates 1017320..1017847 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LRP35_RS04905 Protein ID WP_000855694.1
Coordinates 1017844..1018134 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP35_RS04870 (1013620) 1013620..1014017 + 398 Protein_955 cytoplasmic protein -
LRP35_RS04875 (1014208) 1014208..1014447 + 240 Protein_956 hypothetical protein -
LRP35_RS04880 (1014604) 1014604..1015272 + 669 WP_000445914.1 hypothetical protein -
LRP35_RS04885 (1015299) 1015299..1015793 + 495 WP_000424942.1 hypothetical protein -
LRP35_RS04890 (1016038) 1016038..1016694 - 657 WP_020437799.1 protein-serine/threonine phosphatase -
LRP35_RS04895 (1017032) 1017032..1017247 + 216 Protein_960 IS5/IS1182 family transposase -
LRP35_RS04900 (1017320) 1017320..1017847 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LRP35_RS04905 (1017844) 1017844..1018134 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LRP35_RS04910 (1018404) 1018404..1018604 - 201 Protein_963 transposase -
LRP35_RS04915 (1018845) 1018845..1019171 + 327 WP_000393302.1 hypothetical protein -
LRP35_RS04920 (1019444) 1019444..1019791 - 348 WP_001669174.1 DUF1493 family protein -
LRP35_RS04925 (1019776) 1019776..1020225 - 450 WP_021294302.1 hypothetical protein -
LRP35_RS04930 (1020657) 1020657..1021100 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LRP35_RS04935 (1021556) 1021556..1022206 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1017107..1017247 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T227099 WP_000971655.1 NZ_CP088901:c1017847-1017320 [Salmonella enterica subsp. enterica serovar Muenchen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T227099 NZ_CP122719:1981870-1982124 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT227099 WP_000855694.1 NZ_CP088901:c1018134-1017844 [Salmonella enterica subsp. enterica serovar Muenchen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT227099 NZ_CP122719:1981622-1981873 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References