Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 854712..855372 Replicon chromosome
Accession NZ_CP088901
Organism Salmonella enterica subsp. enterica serovar Muenchen strain 180135033

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LRP35_RS04155 Protein ID WP_000244756.1
Coordinates 854959..855372 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LRP35_RS04150 Protein ID WP_000351186.1
Coordinates 854712..854978 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP35_RS04130 (850640) 850640..852073 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LRP35_RS04135 (852232) 852232..852543 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LRP35_RS04140 (852707) 852707..853366 + 660 WP_000250289.1 hemolysin III family protein -
LRP35_RS04145 (853482) 853482..854462 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
LRP35_RS04150 (854712) 854712..854978 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LRP35_RS04155 (854959) 854959..855372 + 414 WP_000244756.1 protein YgfX Toxin
LRP35_RS04160 (855425) 855425..855946 - 522 WP_001055885.1 flavodoxin FldB -
LRP35_RS04165 (856059) 856059..856955 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LRP35_RS04170 (856979) 856979..857692 + 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRP35_RS04175 (857698) 857698..859431 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T227098 WP_000244756.1 NZ_CP088901:854959-855372 [Salmonella enterica subsp. enterica serovar Muenchen]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T227098 NZ_CP122719:1981622-1981873 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT227098 WP_000351186.1 NZ_CP088901:854712-854978 [Salmonella enterica subsp. enterica serovar Muenchen]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227098 NZ_CP122719:1981870-1982124 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References