227096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 6984..7630 Replicon plasmid pDETABR21-1
Accession NZ_CP088896
Organism Acinetobacter baumannii strain DETAB-R21

Toxin (Protein)


Gene name vapC Uniprot ID A0A6G6AQI7
Locus tag LRX86_RS18480 Protein ID WP_063099733.1
Coordinates 6984..7391 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G6AR75
Locus tag LRX86_RS18485 Protein ID WP_063099732.1
Coordinates 7391..7630 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRX86_RS18455 (LRX86_18455) 2377..2664 + 288 WP_096877510.1 BrnT family toxin -
LRX86_RS18460 (LRX86_18460) 2651..2965 + 315 WP_001983304.1 BrnA antitoxin family protein -
LRX86_RS18465 (LRX86_18465) 3093..5504 + 2412 WP_096877509.1 TonB-dependent receptor ZnuD2 -
LRX86_RS18470 (LRX86_18470) 5809..6270 + 462 WP_000761346.1 DIP1984 family protein -
LRX86_RS18475 (LRX86_18475) 6616..6921 - 306 WP_062911967.1 hypothetical protein -
LRX86_RS18480 (LRX86_18480) 6984..7391 - 408 WP_063099733.1 type II toxin-antitoxin system VapC family toxin Toxin
LRX86_RS18485 (LRX86_18485) 7391..7630 - 240 WP_063099732.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRX86_RS18490 (LRX86_18490) 7833..8396 + 564 WP_050660967.1 GNAT family N-acetyltransferase -
LRX86_RS18495 (LRX86_18495) 8762..9646 + 885 WP_032011147.1 nucleotide-binding protein -
LRX86_RS18500 (LRX86_18500) 9689..9880 - 192 WP_032011142.1 hypothetical protein -
LRX86_RS18505 (LRX86_18505) 10583..11056 + 474 WP_032011144.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..12709 12709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(8-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15312.65 Da        Isoelectric Point: 6.2815

>T227096 WP_063099733.1 NZ_CP088896:c7391-6984 [Acinetobacter baumannii]
MEYLLDTNIVGYLLQGVASNKLKNKLMMVNPDSVFISQITHAEIVYGLEKGGNIPKHIDRVNSFLETLSILDWDDQCAHA
YGKVRNELRLQGVTVQSMDLMIGAHALGHHLILVSNDHIFDHFKQFGLVLENWQI

Download         Length: 408 bp

>T227096 NZ_CP122719:909891-910298 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9360.58 Da        Isoelectric Point: 5.8451

>AT227096 WP_063099732.1 NZ_CP088896:c7630-7391 [Acinetobacter baumannii]
MNHTAKVFMNGQSQAVRLPKQFRFESKTVYVRRNTKGEVILSEKPRTWADFFEENTDMSGFETLMADREQDIPIERDIF

Download         Length: 240 bp

>AT227096 NZ_CP122719:909644-909910 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6AQI7

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6AR75

References