Detailed information of TA system TA227094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3173814..3174492
• Replicon: chromosome
• Accession: NZ_CP088895
• Organism: Acinetobacter baumannii strain DETAB-R21

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LRX86_RS15165
• Protein ID: WP_000009390.1
• Coordinates: 3173814..3173993 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A009Q2Y3
• Locus tag: LRX86_RS15170
• Protein ID: WP_032058837.1
• Coordinates: 3174079..3174492 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRX86_RS15145 (LRX86_15145)	3169620..3170480	-	861	WP_196085344.1	GPO family capsid scaffolding protein	-
LRX86_RS15150 (LRX86_15150)	3170659..3172437	+	1779	WP_196085343.1	terminase family protein	-
LRX86_RS15155 (LRX86_15155)	3172434..3173480	+	1047	WP_254231395.1	phage portal protein	-
LRX86_RS15160 (LRX86_15160)	3173491..3173706	+	216	WP_227552920.1	hypothetical protein	-
LRX86_RS15165 (LRX86_15165)	3173814..3173993	+	180	WP_000009390.1	type II toxin-antitoxin system HicA family toxin	Toxin
LRX86_RS15170 (LRX86_15170)	3174079..3174492	+	414	WP_032058837.1	antitoxin	Antitoxin
LRX86_RS15195 (LRX86_15195)	3176461..3177525	-	1065	WP_001278262.1	quinolinate synthase NadA	-
LRX86_RS15200 (LRX86_15200)	3177672..3178892	-	1221	WP_000268130.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3100837..3174492	73655

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (16-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6799.11 Da
• Isoelectric Point: 11.1422

>T227094 WP_000009390.1 NZ_CP088895:3173814-3173993 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T227094 NZ_CP122719:c616598-616134 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATAGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCGATTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15334.70 Da
• Isoelectric Point: 6.2451

>AT227094 WP_032058837.1 NZ_CP088895:3174079-3174492 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYAVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Nucleotide

• Length: 414 bp

>AT227094 NZ_CP122719:c616933-616598 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A009Q2Y3