Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 526429..527082 Replicon chromosome
Accession NZ_CP088895
Organism Acinetobacter baumannii strain DETAB-R21

Toxin (Protein)


Gene name cptA Uniprot ID A0A009H6L2
Locus tag LRX86_RS02545 Protein ID WP_002086511.1
Coordinates 526693..527082 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LRX86_RS02540 Protein ID WP_001288210.1
Coordinates 526429..526686 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRX86_RS02520 (LRX86_02520) 521945..522952 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
LRX86_RS02525 (LRX86_02525) 522971..523348 + 378 WP_001216380.1 50S ribosomal protein L17 -
LRX86_RS02530 (LRX86_02530) 523530..525020 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
LRX86_RS02535 (LRX86_02535) 525069..526241 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
LRX86_RS02540 (LRX86_02540) 526429..526686 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LRX86_RS02545 (LRX86_02545) 526693..527082 + 390 WP_002086511.1 hypothetical protein Toxin
LRX86_RS02550 (LRX86_02550) 527852..528937 + 1086 WP_000049106.1 hypothetical protein -
LRX86_RS02555 (LRX86_02555) 529015..529581 + 567 WP_000651536.1 rhombosortase -
LRX86_RS02560 (LRX86_02560) 529769..531964 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15623.95 Da        Isoelectric Point: 10.5355

>T227093 WP_002086511.1 NZ_CP088895:526693-527082 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Download         Length: 390 bp

>T227093 NZ_CP122718:c5782-5408 [Escherichia coli]
ATGATATTAGTAGATACGTCTGTGTGGGTTGATCATTTTAAAAATAAAAATGATACATTGATTCAGCTATTGCAGTCAGA
CTTTGTTCTTATGCACCCCATGATCCTGGCTGAAATTGCATGCGGCACACCGCCAGCGCCCAGGCAGCGAACATTGAGTG
ATTTAGACTTGTTACCGAAAAGTCATCAGGCCACGATCACTGAAGTTCTGGCGTTCATTGAAAATGAAAAATTATTCGGA
CTGGGTTGTGGTCTGGTTGATATAACATTATTAGCGTCAACGAGGATTACCCCCGGGGCTAAAATATGGACGCTGGATAA
GCGACTGTCACGACTGGCAAAACACCTGAATGTAGAATATCAGCCTGTACATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT227093 WP_001288210.1 NZ_CP088895:526429-526686 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT227093 NZ_CP122718:c5982-5779 [Escherichia coli]
ATGAGAACTACTGTAACGATCGACGATGTTCTGTACGCACAGGCGCTGGAAATGGCTGATCCGGGTATGGATAAATCAGA
TATTTTCCGTGAAGCTGTGAAAACGTTTATTCGTGTGCAGGCTGCGAAACGCCTGGCTTCACTTGGTGGAGCTGCCCCGA
ATATGGAGATAACACCACGCAGGCGTGGAGATGTGGCAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009H6L2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References