Detailed information of TA system TA227092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3058867..3059545
• Replicon: chromosome
• Accession: NZ_CP088894
• Organism: Acinetobacter baumannii strain XH1935

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LRX85_RS14650
• Protein ID: WP_000009390.1
• Coordinates: 3058867..3059046 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A009Q2Y3
• Locus tag: LRX85_RS14655
• Protein ID: WP_032058837.1
• Coordinates: 3059132..3059545 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRX85_RS14630 (LRX85_14630)	3054673..3055533	-	861	WP_196085344.1	GPO family capsid scaffolding protein	-
LRX85_RS14635 (LRX85_14635)	3055712..3057490	+	1779	WP_196085343.1	terminase family protein	-
LRX85_RS14640 (LRX85_14640)	3057487..3058533	+	1047	WP_254231395.1	phage portal protein	-
LRX85_RS14645 (LRX85_14645)	3058544..3058759	+	216	WP_227552920.1	hypothetical protein	-
LRX85_RS14650 (LRX85_14650)	3058867..3059046	+	180	WP_000009390.1	type II toxin-antitoxin system HicA family toxin	Toxin
LRX85_RS14655 (LRX85_14655)	3059132..3059545	+	414	WP_032058837.1	antitoxin	Antitoxin
LRX85_RS14680 (LRX85_14680)	3061514..3062578	-	1065	WP_001278262.1	quinolinate synthase NadA	-
LRX85_RS14685 (LRX85_14685)	3062725..3063945	-	1221	WP_000268130.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3017368..3059545	42177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (16-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6799.11 Da
• Isoelectric Point: 11.1422

>T227092 WP_000009390.1 NZ_CP088894:3058867-3059046 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T227092 NZ_CP122717:c51189-50902 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGTGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15334.70 Da
• Isoelectric Point: 6.2451

>AT227092 WP_032058837.1 NZ_CP088894:3059132-3059545 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYAVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Nucleotide

• Length: 414 bp

>AT227092 NZ_CP122717:c51437-51186 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCCTAGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGATCTGGAT
AAATACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A009Q2Y3