Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 410300..410953 Replicon chromosome
Accession NZ_CP088894
Organism Acinetobacter baumannii strain XH1935

Toxin (Protein)


Gene name cptA Uniprot ID A0A009H6L2
Locus tag LRX85_RS02030 Protein ID WP_002086511.1
Coordinates 410564..410953 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LRX85_RS02025 Protein ID WP_001288210.1
Coordinates 410300..410557 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRX85_RS02005 (LRX85_02005) 405816..406823 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
LRX85_RS02010 (LRX85_02010) 406842..407219 + 378 WP_001216380.1 50S ribosomal protein L17 -
LRX85_RS02015 (LRX85_02015) 407401..408891 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
LRX85_RS02020 (LRX85_02020) 408940..410112 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
LRX85_RS02025 (LRX85_02025) 410300..410557 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LRX85_RS02030 (LRX85_02030) 410564..410953 + 390 WP_002086511.1 hypothetical protein Toxin
LRX85_RS02035 (LRX85_02035) 411723..412808 + 1086 WP_000049106.1 hypothetical protein -
LRX85_RS02040 (LRX85_02040) 412886..413452 + 567 WP_000651536.1 rhombosortase -
LRX85_RS02045 (LRX85_02045) 413640..415835 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15623.95 Da        Isoelectric Point: 10.5355

>T227091 WP_002086511.1 NZ_CP088894:410564-410953 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Download         Length: 390 bp

>T227091 NZ_CP122717:19245-19523 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT227091 WP_001288210.1 NZ_CP088894:410300-410557 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT227091 NZ_CP122717:18976-19245 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009H6L2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References