Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 282304..282974 Replicon plasmid pPT1018
Accession NZ_CP088293
Organism Phyllobacterium sp. T1018

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE51_RS18225 Protein ID WP_091951185.1
Coordinates 282531..282974 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLE51_RS18220 Protein ID WP_091923596.1
Coordinates 282304..282534 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE51_RS18195 (LLE51_018195) 277503..278615 + 1113 WP_228019909.1 4-hydroxyphenylpyruvate dioxygenase -
LLE51_RS18200 (LLE51_018200) 278705..279358 - 654 WP_228019911.1 maleylacetoacetate isomerase -
LLE51_RS18205 (LLE51_018205) 279348..280361 - 1014 WP_228019913.1 fumarylacetoacetate hydrolase family protein -
LLE51_RS18210 (LLE51_018210) 280362..281690 - 1329 WP_228019916.1 homogentisate 1,2-dioxygenase -
LLE51_RS18215 (LLE51_018215) 281764..282216 + 453 WP_113281430.1 MarR family transcriptional regulator -
LLE51_RS18220 (LLE51_018220) 282304..282534 + 231 WP_091923596.1 CopG family transcriptional regulator Antitoxin
LLE51_RS18225 (LLE51_018225) 282531..282974 + 444 WP_091951185.1 PIN domain-containing protein Toxin
LLE51_RS18230 (LLE51_018230) 282971..283732 - 762 WP_027232293.1 ABC transporter permease -
LLE51_RS18235 (LLE51_018235) 283729..284655 - 927 WP_091923493.1 ABC transporter ATP-binding protein -
LLE51_RS18240 (LLE51_018240) 284848..286062 - 1215 WP_027232295.1 MFS transporter -
LLE51_RS18245 (LLE51_018245) 286191..287015 + 825 WP_228019919.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..388677 388677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(5-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15984.15 Da        Isoelectric Point: 6.3685

>T227090 WP_091951185.1 NZ_CP088293:282531-282974 [Phyllobacterium sp. T1018]
VTPYLLDVNVLIALFDPAHVHHDPAHEWFADIGRSSWATCPITENGAIRIISSARYPNSPGTPAAVVALLAGLRAIPGHV
FWPDDISLMDNSIDPSRLLNAGQVTDTYLLALAQAHQGKLATFDRRLVTDAVRDGRNCLHVIGERTT

Download         Length: 444 bp

>T227090 NZ_CP122712:c4788026-4787853 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8108.33 Da        Isoelectric Point: 10.4579

>AT227090 WP_091923596.1 NZ_CP088293:282304-282534 [Phyllobacterium sp. T1018]
MRTTLAIDDDVLAAAKGLAERQRKTVGEVISTLARKGLQAPTARQATRNGVPLLPAGTNSTPVTMELVNQLRDELP

Download         Length: 231 bp

>AT227090 NZ_CP122712:c4788350-4788054 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References