Detailed information of TA system TA227089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3005677..3006278
• Replicon: chromosome
• Accession: NZ_CP088292
• Organism: Phyllobacterium sp. T1018

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LLE51_RS14575
• Protein ID: WP_027231900.1
• Coordinates: 3006012..3006278 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A849VV97
• Locus tag: LLE51_RS14570
• Protein ID: WP_027231899.1
• Coordinates: 3005677..3006015 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLE51_RS14555 (LLE51_014555)	3002293..3003615	-	1323	WP_027231896.1	cell division protein FtsA	-
LLE51_RS14560 (LLE51_014560)	3003612..3004553	-	942	WP_228017977.1	cell division protein FtsQ/DivIB	-
LLE51_RS14565 (LLE51_014565)	3004541..3005467	-	927	WP_027231898.1	D-alanine--D-alanine ligase	-
LLE51_RS14570 (LLE51_014570)	3005677..3006015	-	339	WP_027231899.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LLE51_RS14575 (LLE51_014575)	3006012..3006278	-	267	WP_027231900.1	type II toxin-antitoxin system HicA family toxin	Toxin
LLE51_RS14580 (LLE51_014580)	3006343..3007317	-	975	WP_091945028.1	UDP-N-acetylmuramate dehydrogenase	-
LLE51_RS14585 (LLE51_014585)	3007375..3008775	-	1401	WP_228017976.1	UDP-N-acetylmuramate--L-alanine ligase	-
LLE51_RS14590 (LLE51_014590)	3008772..3009899	-	1128	WP_228017975.1	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	-
LLE51_RS14595 (LLE51_014595)	3009906..3011063	-	1158	WP_027231904.1	putative lipid II flippase FtsW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (27-79)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9950.55 Da
• Isoelectric Point: 11.6528

>T227089 WP_027231900.1 NZ_CP088292:c3006278-3006012 [Phyllobacterium sp. T1018]
MVLNLKRRHRVILQQVFARPASGSIRWSDVEALLLGLGAEITEREGSRIGVFLFGEIRVFHRPHPSPDTDKGAIASIRKW
LESHGIRP

Nucleotide

• Length: 267 bp

>T227089 NZ_CP122712:c4525620-4525333 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAACAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12233.85 Da
• Isoelectric Point: 4.5094

>AT227089 WP_027231899.1 NZ_CP088292:c3006015-3005677 [Phyllobacterium sp. T1018]
MKNVIQIEGHKAVVSYDPDIEMIRGEFLGLSGGADFYADSVEGLMEEGRRSLKVYLDMCAEKGIAPFREYSGRFNVRLPA
EIHEAAVLAAASENKSLNEWVAEAIEAAARAA

Nucleotide

• Length: 339 bp

>AT227089 NZ_CP122712:c4525346-4525044 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A849VV97