Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1899080..1899673 Replicon chromosome
Accession NZ_CP088292
Organism Phyllobacterium sp. T1018

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LLE51_RS09195 Protein ID WP_228018646.1
Coordinates 1899485..1899673 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LLE51_RS09190 Protein ID WP_228018647.1
Coordinates 1899080..1899481 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE51_RS09165 (LLE51_009165) 1895095..1895994 - 900 WP_228018648.1 DMT family transporter -
LLE51_RS09170 (LLE51_009170) 1896057..1896803 - 747 WP_091918948.1 arginyltransferase -
LLE51_RS09175 (LLE51_009175) 1896914..1897327 - 414 WP_051615124.1 hypothetical protein -
LLE51_RS09180 (LLE51_009180) 1897399..1897869 - 471 WP_027232382.1 RDD family protein -
LLE51_RS09185 (LLE51_009185) 1897949..1898986 - 1038 WP_027232383.1 porphobilinogen synthase -
LLE51_RS09190 (LLE51_009190) 1899080..1899481 - 402 WP_228018647.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LLE51_RS09195 (LLE51_009195) 1899485..1899673 - 189 WP_228018646.1 type II toxin-antitoxin system HicA family toxin Toxin
LLE51_RS09200 (LLE51_009200) 1899781..1900836 + 1056 WP_228018645.1 enoyl-CoA hydratase/isomerase family protein -
LLE51_RS09205 (LLE51_009205) 1900833..1901261 + 429 WP_027232385.1 DUF6163 family protein -
LLE51_RS09210 (LLE51_009210) 1901424..1901939 + 516 WP_027232386.1 winged helix DNA-binding protein -
LLE51_RS09215 (LLE51_009215) 1902265..1903542 + 1278 WP_027232387.1 L,D-transpeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7030.14 Da        Isoelectric Point: 11.3076

>T227088 WP_228018646.1 NZ_CP088292:c1899673-1899485 [Phyllobacterium sp. T1018]
MKSGDVIALLEKDGWREVARKGSHVQFKHPEKPGRVTVPHPKRDIPIGTLRSFERQSGLSLR

Download         Length: 189 bp

>T227088 NZ_CP122712:4184152-4184430 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14402.09 Da        Isoelectric Point: 4.3518

>AT227088 WP_228018647.1 NZ_CP088292:c1899481-1899080 [Phyllobacterium sp. T1018]
MQHYIGLIHKDADSDYGVSFPDFPGVVTAGTSLDDAHAMADEALSFHIEGLIEDGEAIPEPSRLEDIMAYPDNRSSVAIL
VAVKTDAKRAVRVNVTLPEDILQQIDTYAEAHGFTRSGFLAQAAKKAMERDAA

Download         Length: 402 bp

>AT227088 NZ_CP122712:4183889-4184149 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References