Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1117619..1118250 Replicon chromosome
Accession NZ_CP088292
Organism Phyllobacterium sp. T1018

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE51_RS05415 Protein ID WP_228017097.1
Coordinates 1117619..1118011 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLE51_RS05420 Protein ID WP_228017095.1
Coordinates 1118008..1118250 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE51_RS05395 (LLE51_005395) 1113038..1114921 - 1884 WP_228017099.1 extracellular solute-binding protein -
LLE51_RS05400 (LLE51_005400) 1115062..1115751 - 690 WP_027230411.1 cytochrome c family protein -
LLE51_RS05405 (LLE51_005405) 1116012..1116752 + 741 WP_027230410.1 3-deoxy-manno-octulosonate cytidylyltransferase -
LLE51_RS05410 (LLE51_005410) 1116755..1117618 + 864 WP_228017098.1 prephenate dehydratase -
LLE51_RS05415 (LLE51_005415) 1117619..1118011 - 393 WP_228017097.1 type II toxin-antitoxin system VapC family toxin Toxin
LLE51_RS05420 (LLE51_005420) 1118008..1118250 - 243 WP_228017095.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LLE51_RS05425 (LLE51_005425) 1118326..1119252 - 927 WP_228017093.1 NAD(+) diphosphatase -
LLE51_RS05430 (LLE51_005430) 1119307..1119711 - 405 WP_228019308.1 HIT family protein -
LLE51_RS05440 (LLE51_005440) 1119995..1121806 + 1812 Protein_1070 DNA polymerase III subunit gamma/tau -
LLE51_RS05445 (LLE51_005445) 1121825..1122148 + 324 WP_027230406.1 YbaB/EbfC family nucleoid-associated protein -
LLE51_RS05450 (LLE51_005450) 1122558..1123163 + 606 WP_027230405.1 recombination mediator RecR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14736.82 Da        Isoelectric Point: 6.7299

>T227087 WP_228017097.1 NZ_CP088292:c1118011-1117619 [Phyllobacterium sp. T1018]
MTYLLDTNAVIALLKFNDKFRSNMMRHSPQDIAISAIVAHELYFGAYKSERREKNLADIEILQFQILEFSQEDARSAGAL
RAHLSREGTPIGPYDVLIAGQARARSLVLVTRNVREFERIGGLTIENWEG

Download         Length: 393 bp

>T227087 NZ_CP122712:c4178090-4177692 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGCTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9292.27 Da        Isoelectric Point: 4.3885

>AT227087 WP_228017095.1 NZ_CP088292:c1118250-1118008 [Phyllobacterium sp. T1018]
VDTAKIFWSGRSQAVRLPKEFRFETSEVRIRRQGNAVILEPIANDWAWLSELSGHVDEDFEQAASEQPEAQERPDLDFFK

Download         Length: 243 bp

>AT227087 NZ_CP122712:c4178386-4178093 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References