Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 353242..353821 Replicon chromosome
Accession NZ_CP088292
Organism Phyllobacterium sp. T1018

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LLE51_RS01825 Protein ID WP_228017616.1
Coordinates 353510..353821 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LLE51_RS01820 Protein ID WP_027231071.1
Coordinates 353242..353529 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE51_RS01805 (LLE51_001805) 348810..349346 - 537 WP_113281656.1 D-Ala-D-Ala carboxypeptidase family metallohydrolase -
LLE51_RS01810 (LLE51_001810) 349640..351592 + 1953 WP_228017618.1 acetate--CoA ligase -
LLE51_RS01815 (LLE51_001815) 351628..352893 - 1266 WP_228017617.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
LLE51_RS01820 (LLE51_001820) 353242..353529 - 288 WP_027231071.1 putative addiction module antidote protein Antitoxin
LLE51_RS01825 (LLE51_001825) 353510..353821 - 312 WP_228017616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE51_RS01830 (LLE51_001830) 354072..355409 + 1338 WP_234576118.1 MATE family efflux transporter -
LLE51_RS01835 (LLE51_001835) 355406..355639 - 234 WP_091921556.1 DUF1674 domain-containing protein -
LLE51_RS01840 (LLE51_001840) 355764..356738 + 975 WP_091920921.1 zinc metalloprotease HtpX -
LLE51_RS01845 (LLE51_001845) 356735..358117 + 1383 WP_228017614.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-90)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11776.48 Da        Isoelectric Point: 10.1339

>T227085 WP_228017616.1 NZ_CP088292:c353821-353510 [Phyllobacterium sp. T1018]
MIGLKQTSVYRKWESKLKDQRARAVIAARLFRLASGLGSDIAFVGGGVSELRIHYGPGYRVYFRRHGEQIVILLCGGDKQ
TQDRDIREARRLAIDWRDDDEAL

Download         Length: 312 bp

>T227085 NZ_CP122712:3178910-3179188 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10119.55 Da        Isoelectric Point: 6.2972

>AT227085 WP_027231071.1 NZ_CP088292:c353529-353242 [Phyllobacterium sp. T1018]
MMTKLYDYNPADALKSDEAIELFLADAFETGDSAYIAKAIGVVARSKGMATIARETGLSREQLYRSLSESGNPTLATTIA
VLKAVGFQLSGKRAA

Download         Length: 288 bp

>AT227085 NZ_CP122712:3178717-3178908 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References