Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 20277..20998 Replicon chromosome
Accession NZ_CP088292
Organism Phyllobacterium sp. T1018

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE51_RS00085 Protein ID WP_228017767.1
Coordinates 20585..20998 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLE51_RS00080 Protein ID WP_027229662.1
Coordinates 20277..20546 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE51_RS00065 (LLE51_000065) 15325..16404 - 1080 WP_091921324.1 peptide chain release factor 1 -
LLE51_RS00070 (LLE51_000070) 16414..18708 - 2295 WP_036813038.1 phosphoenolpyruvate--protein phosphotransferase -
LLE51_RS00075 (LLE51_000075) 18800..20053 - 1254 WP_027229661.1 aspartate kinase -
LLE51_RS00080 (LLE51_000080) 20277..20546 + 270 WP_027229662.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LLE51_RS00085 (LLE51_000085) 20585..20998 + 414 WP_228017767.1 type II toxin-antitoxin system VapC family toxin Toxin
LLE51_RS00090 (LLE51_000090) 21067..21810 + 744 WP_228017766.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
LLE51_RS00095 (LLE51_000095) 21797..22711 - 915 WP_228017765.1 DMT family transporter -
LLE51_RS00100 (LLE51_000100) 22772..23185 - 414 WP_228017764.1 DUF1178 family protein -
LLE51_RS00105 (LLE51_000105) 23182..24048 - 867 WP_228017763.1 carbon-nitrogen hydrolase family protein -
LLE51_RS00110 (LLE51_000110) 24059..24328 - 270 WP_091921308.1 glutaredoxin 3 -
LLE51_RS00115 (LLE51_000115) 24406..25185 - 780 WP_228017762.1 ComF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(10-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15209.56 Da        Isoelectric Point: 7.0606

>T227084 WP_228017767.1 NZ_CP088292:20585-20998 [Phyllobacterium sp. T1018]
MLHMLDTDIASYIIKGRSPKIDEKLSELQPSDVCVSAITKAELLYGLKRIPENHRLHGEISRFFQIVRVLAWDAVAAEYY
AGIRHQLVSTGQPIGELDMMIAAHSISVGAVLVSNNTRHYQRISGGLALANWAQLEV

Download         Length: 414 bp

>T227084 NZ_CP122712:c2977092-2976989 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10236.37 Da        Isoelectric Point: 4.3006

>AT227084 WP_027229662.1 NZ_CP088292:20277-20546 [Phyllobacterium sp. T1018]
MTEVRIAKLFKNGASQAVRLPADFRFDGDEVYVSRDDRTGDVILSTRPGARVWADFFELRNSVEVPDDFMGERPMNAFPV
ERSFFDEND

Download         Length: 270 bp

>AT227084 NZ_CP122712:2976951-2977222 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References