Detailed information of TA system TA022708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1649999..1650597
• Replicon: chromosome
• Accession: NC_010475
• Organism: Synechococcus sp. PCC 7002

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SYNPCC7002_RS16450
• Protein ID: WP_030007036.1
• Coordinates: 1649999..1650253 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B1XNN0
• Locus tag: SYNPCC7002_RS07840
• Protein ID: WP_012307178.1
• Coordinates: 1650250..1650597 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCC7002_RS07815	1645160..1646542	-	1383	WP_030008145.1	photosystem II reaction center protein CP43	-
SYNPCC7002_RS07820	1646526..1647584	-	1059	WP_012307174.1	photosystem II D2 protein (photosystem q(a) protein)	-
SYNPCC7002_RS07825	1647899..1648456	-	558	WP_012307175.1	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	-
SYNPCC7002_RS07830	1648493..1649365	-	873	WP_041443863.1	prolipoprotein diacylglyceryl transferase	-
SYNPCC7002_RS07835	1649365..1649766	-	402	WP_012307177.1	preQ(1) synthase	-
SYNPCC7002_RS16450	1649999..1650253	+	255	WP_030007036.1	type II toxin-antitoxin system HicA family toxin	Toxin
SYNPCC7002_RS07840	1650250..1650597	+	348	WP_012307178.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SYNPCC7002_RS07845	1650648..1650941	-	294	WP_012307179.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
SYNPCC7002_RS07850	1650994..1651515	-	522	WP_012307180.1	photosystem I assembly protein Ycf3	-
SYNPCC7002_RS07855	1651584..1652564	+	981	WP_012307181.1	DNA polymerase III subunit delta	-
SYNPCC7002_RS07860	1652685..1653167	+	483	WP_012307182.1	DUF4168 domain-containing protein	-
SYNPCC7002_RS07865	1653303..1654172	-	870	WP_012307183.1	M48 family metalloprotease	-
SYNPCC7002_RS07870	1654309..1654590	-	282	WP_012307184.1	hypothetical protein	-
SYNPCC7002_RS07875	1654817..1655101	-	285	WP_012307185.1	DUF2470 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9322.80 Da
• Isoelectric Point: 11.0285

>T22708 WP_030007036.1 NC_010475:1649999-1650253 [Synechococcus sp. PCC 7002]
MKRKNSKTLALIFQRPISGNIAWSDIEALFLELGADISERSGSRVAVILFGEVRVFHRPHPSPTTDKGAVASIRKWLESH
GVKP

Nucleotide

• Length: 255 bp

>T22708 NC_010475:1649999-1650253 [Synechococcus sp. PCC 7002]
ATGAAGCGTAAAAACAGTAAAACCCTAGCGCTTATTTTCCAAAGGCCCATCAGTGGCAACATTGCCTGGTCTGACATCGA
AGCACTCTTTCTGGAACTAGGAGCAGACATTTCTGAGAGGAGTGGCTCACGAGTTGCGGTGATTCTCTTTGGTGAAGTGC
GGGTTTTTCATCGACCTCACCCTTCCCCTACAACTGATAAAGGAGCCGTTGCCAGTATTCGGAAATGGTTAGAATCCCAC
GGAGTAAAGCCATGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13104.88 Da
• Isoelectric Point: 4.6044

>AT22708 WP_012307178.1 NC_010475:1650250-1650597 [Synechococcus sp. PCC 7002]
MNMMILDGYRAKIEYDPELDLFRGEILGLNGGADFYGSNPEELRQEFKNSLAVFLEVCKEKGISPIKEYSGRFNLRVSPE
LHREIAILTASKNTSINKWITEVLQEAVQSTDYAQ

Nucleotide

• Length: 348 bp

>AT22708 NC_010475:1650250-1650597 [Synechococcus sp. PCC 7002]
ATGAACATGATGATTCTTGATGGTTATCGAGCAAAAATTGAATATGACCCAGAACTTGACTTATTTCGCGGTGAAATCTT
GGGGTTAAATGGTGGCGCAGATTTCTATGGCAGCAATCCCGAAGAACTCCGCCAGGAATTTAAAAATTCCCTCGCAGTAT
TTCTCGAAGTTTGTAAAGAAAAAGGCATTAGCCCCATCAAAGAATATTCAGGACGCTTTAACCTACGAGTTTCACCAGAG
CTACACCGTGAAATCGCAATTTTGACGGCCAGCAAAAATACCAGCATCAATAAGTGGATTACCGAAGTTCTGCAGGAAGC
GGTGCAATCTACTGATTATGCCCAATAA

Structures

Antitoxin

• AlphaFold DB: B1XNN0