Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 86900..87489 Replicon plasmid pT1293a
Accession NZ_CP088275
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LLE53_RS20305 Protein ID WP_227988932.1
Coordinates 87154..87489 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LLE53_RS20300 Protein ID WP_234528107.1
Coordinates 86900..87154 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS20280 (LLE53_020280) 83316..83783 - 468 WP_227988927.1 MarR family transcriptional regulator -
LLE53_RS20285 (LLE53_020285) 83867..85183 + 1317 WP_227988928.1 homogentisate 1,2-dioxygenase -
LLE53_RS20290 (LLE53_020290) 85180..86199 + 1020 WP_227988929.1 fumarylacetoacetate hydrolase family protein -
LLE53_RS20295 (LLE53_020295) 86203..86847 + 645 WP_227988930.1 maleylacetoacetate isomerase -
LLE53_RS20300 (LLE53_020300) 86900..87154 + 255 WP_234528107.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LLE53_RS20305 (LLE53_020305) 87154..87489 + 336 WP_227988932.1 endoribonuclease MazF Toxin
LLE53_RS20310 (LLE53_020310) 87492..88604 - 1113 WP_112522399.1 4-hydroxyphenylpyruvate dioxygenase -
LLE53_RS20315 (LLE53_020315) 88725..89186 + 462 WP_113094968.1 Lrp/AsnC family transcriptional regulator -
LLE53_RS20320 (LLE53_020320) 89269..89514 + 246 WP_113094969.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LLE53_RS20325 (LLE53_020325) 89527..89748 + 222 Protein_82 type II toxin-antitoxin system RelE/ParE family toxin -
LLE53_RS20330 (LLE53_020330) 89775..90113 - 339 WP_112522395.1 type II toxin-antitoxin system PemK/MazF family toxin -
LLE53_RS20335 (LLE53_020335) 90100..90318 - 219 WP_112522394.1 type II toxin-antitoxin system PrlF family antitoxin -
LLE53_RS20340 (LLE53_020340) 90386..91072 - 687 WP_227989252.1 ligase-associated DNA damage response endonuclease PdeM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..519835 519835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin

SpoVT-AbrB domain

(10-52)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12087.99 Da        Isoelectric Point: 9.8578

>T227069 WP_227988932.1 NZ_CP088275:87154-87489 [Phyllobacterium sp. T1293]
MPAYVPDAGDIVWLHFNPQAGHEQAGHRPAVVLSPASYNGRIGLMLCCPMTTQIKGYPFEVAIASDRPSAVLADQVKSLD
WRVRRATYKGKISASELAEIRNKAAALIGKR

Download         Length: 336 bp

>T227069 NZ_CP122712:c623033-622569 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9379.73 Da        Isoelectric Point: 4.2070

>AT227069 WP_234528107.1 NZ_CP088275:86900-87154 [Phyllobacterium sp. T1293]
MEYVMRVTVKKWGNSASVRIPAAVMAAARLELDTLVDVREEEGLIIIEPVRQVEYDLDRLIEGITPENIHSEADFGDPVG
KEAL

Download         Length: 255 bp

>AT227069 NZ_CP122712:c623368-623033 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References