Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 3266968..3267586 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LLE53_RS16070 Protein ID WP_113095556.1
Coordinates 3266968..3267318 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LLE53_RS16075 Protein ID WP_112522904.1
Coordinates 3267299..3267586 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS16050 (LLE53_016050) 3262702..3264087 - 1386 WP_227987651.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
LLE53_RS16055 (LLE53_016055) 3264078..3265043 - 966 WP_227987652.1 zinc metalloprotease HtpX -
LLE53_RS16060 (LLE53_016060) 3265159..3265392 + 234 WP_227987653.1 DUF1674 domain-containing protein -
LLE53_RS16065 (LLE53_016065) 3265412..3266812 - 1401 WP_227987654.1 MATE family efflux transporter -
LLE53_RS16070 (LLE53_016070) 3266968..3267318 + 351 WP_113095556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE53_RS16075 (LLE53_016075) 3267299..3267586 + 288 WP_112522904.1 putative addiction module antidote protein Antitoxin
LLE53_RS16080 (LLE53_016080) 3267941..3269206 + 1266 WP_227987655.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
LLE53_RS16085 (LLE53_016085) 3269432..3271384 - 1953 WP_113095416.1 acetate--CoA ligase -
LLE53_RS16090 (LLE53_016090) 3271681..3272223 + 543 WP_227987656.1 D-Ala-D-Ala carboxypeptidase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(14-107)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13205.17 Da        Isoelectric Point: 10.3555

>T227068 WP_113095556.1 NZ_CP088273:3266968-3267318 [Phyllobacterium sp. T1293]
IWTFRNLKNTVLTRIKQTDTYRIWERKLRDDSAKAAIAARLFRLANGLIGDVSSVGEGVHELRVHYGPGYRIYFKQCSTE
LVILLCGGNKRTQQRDIGKAKLLAAEWKNDNGNEAI

Download         Length: 351 bp

>T227068 NZ_CP122712:196449-196556 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10157.61 Da        Isoelectric Point: 6.3033

>AT227068 WP_112522904.1 NZ_CP088273:3267299-3267586 [Phyllobacterium sp. T1293]
MATKLYDYDPADALKSDDAIEVFLADAFETGDAGYIAKALGLVARAKGMTKIARQTGLAREQLYRSLSENGNPTLETTIA
VMKAVGFQITGKRAA

Download         Length: 288 bp

>AT227068 NZ_CP122712:c196401-196335 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References