Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2337931..2338543 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LLE53_RS11520 Protein ID WP_113096410.1
Coordinates 2338361..2338543 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LLE53_RS11515 Protein ID WP_112527092.1
Coordinates 2337931..2338323 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS11490 (LLE53_011490) 2333101..2334189 + 1089 WP_227987198.1 esterase-like activity of phytase family protein -
LLE53_RS11495 (LLE53_011495) 2334207..2335304 - 1098 WP_227987199.1 ABC transporter substrate-binding protein -
LLE53_RS11500 (LLE53_011500) 2335301..2336686 - 1386 WP_227987200.1 sensor histidine kinase -
LLE53_RS11505 (LLE53_011505) 2336676..2337356 - 681 WP_182510909.1 response regulator transcription factor -
LLE53_RS11510 (LLE53_011510) 2337468..2337905 + 438 WP_227987201.1 acetyltransferase -
LLE53_RS11515 (LLE53_011515) 2337931..2338323 - 393 WP_112527092.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LLE53_RS11520 (LLE53_011520) 2338361..2338543 - 183 WP_113096410.1 type II toxin-antitoxin system HicA family toxin Toxin
LLE53_RS11530 (LLE53_011530) 2339156..2339611 - 456 WP_091883437.1 phasin -
LLE53_RS11535 (LLE53_011535) 2339902..2343099 + 3198 WP_227987202.1 PAS domain S-box protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6765.93 Da        Isoelectric Point: 10.9876

>T227065 WP_113096410.1 NZ_CP088273:c2338543-2338361 [Phyllobacterium sp. T1293]
MERDSRKIIKRLKDEGFELVSVSGSHHKFRKGTLTLIVPHPKKDLPIGTARSIAKDAGWL

Download         Length: 183 bp

>T227065 NZ_CP122685:c4891161-4890850 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14233.00 Da        Isoelectric Point: 4.7827

>AT227065 WP_112527092.1 NZ_CP088273:c2338323-2337931 [Phyllobacterium sp. T1293]
MRHYFALVHKDEDSAFGIQFPDIKGVYSAADKADDIVRNAVEALRLYAEDAELPAPSSHGDILARQDIRDELAAGAYLVF
VPLIDNDTAVVRANVTFERGLLRAIDDTVKARGTTRSAFLASAAKREIEA

Download         Length: 393 bp

>AT227065 NZ_CP122685:c4890849-4890559 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References