Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-YozG
Location 2254300..2254942 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LLE53_RS11085 Protein ID WP_227988190.1
Coordinates 2254691..2254942 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LLE53_RS11080 Protein ID WP_227987159.1
Coordinates 2254300..2254698 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS11065 (LLE53_011065) 2251188..2252744 - 1557 WP_112527253.1 NADH-quinone oxidoreductase subunit NuoF -
LLE53_RS11070 (LLE53_011070) 2252741..2253214 - 474 WP_112527251.1 formate dehydrogenase subunit gamma -
LLE53_RS11075 (LLE53_011075) 2253333..2254229 - 897 WP_112527249.1 LysR family transcriptional regulator -
LLE53_RS11080 (LLE53_011080) 2254300..2254698 - 399 WP_227987159.1 helix-turn-helix transcriptional regulator Antitoxin
LLE53_RS11085 (LLE53_011085) 2254691..2254942 - 252 WP_227988190.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE53_RS11090 (LLE53_011090) 2255004..2255699 - 696 WP_227987160.1 urea ABC transporter ATP-binding subunit UrtE -
LLE53_RS11095 (LLE53_011095) 2255758..2256504 - 747 WP_227987161.1 urea ABC transporter ATP-binding protein UrtD -
LLE53_RS11100 (LLE53_011100) 2256509..2257696 - 1188 WP_227987162.1 urea ABC transporter permease subunit UrtC -
LLE53_RS11105 (LLE53_011105) 2257693..2259315 - 1623 WP_227987163.1 urea ABC transporter permease subunit UrtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-79)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9458.98 Da        Isoelectric Point: 10.3118

>T227064 WP_227988190.1 NZ_CP088273:c2254942-2254691 [Phyllobacterium sp. T1293]
MKKIAYSKSALKVLLRIPVNVANRIRSKIEQYADDPALQSMNVTKLQGRNGYRLRVGDWRVIFDDHGNVMDILDIGPRGG
IYE

Download         Length: 252 bp

>T227064 NZ_CP122685:c4591554-4591381 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14714.94 Da        Isoelectric Point: 4.8620

>AT227064 WP_227987159.1 NZ_CP088273:c2254698-2254300 [Phyllobacterium sp. T1293]
MNEIAMGKTAPFTIVKTPANEEMVVIPRTLYDRLVSDAEMARDLAAYDKVKARIDAGEEELVPSEIVERILGGENKVRVW
REYRGLSNQELAEKVGISAPYLSDIQNGKKEGRLSTLKKIAAVLRVDLDDLV

Download         Length: 399 bp

>AT227064 NZ_CP122685:c4591878-4591582 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References