Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2038555..2039186 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE53_RS10050 Protein ID WP_182509875.1
Coordinates 2038788..2039186 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLE53_RS10045 Protein ID WP_113096531.1
Coordinates 2038555..2038791 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS10025 (LLE53_010025) 2035226..2035582 + 357 WP_227987067.1 DUF1636 family protein -
LLE53_RS10030 (LLE53_010030) 2035713..2036522 + 810 WP_227987068.1 ABC transporter ATP-binding protein -
LLE53_RS10035 (LLE53_010035) 2036522..2037469 + 948 WP_227987069.1 ABC transporter substrate-binding protein -
LLE53_RS10040 (LLE53_010040) 2037497..2038489 + 993 WP_113096633.1 iron ABC transporter permease -
LLE53_RS10045 (LLE53_010045) 2038555..2038791 + 237 WP_113096531.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LLE53_RS10050 (LLE53_010050) 2038788..2039186 + 399 WP_182509875.1 type II toxin-antitoxin system VapC family toxin Toxin
LLE53_RS10055 (LLE53_010055) 2039181..2039996 - 816 WP_227987070.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
LLE53_RS10060 (LLE53_010060) 2040173..2042101 - 1929 WP_227988179.1 sulfate adenylyltransferase subunit CysN -
LLE53_RS10065 (LLE53_010065) 2042110..2043015 - 906 WP_227987071.1 sulfate adenylyltransferase subunit CysD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14719.98 Da        Isoelectric Point: 7.1724

>T227063 WP_182509875.1 NZ_CP088273:2038788-2039186 [Phyllobacterium sp. T1293]
MTHTHMLDTNMISGLIRHQNSHLTEKVRQHSKTVCTSIIVAAELRYGVDKKGSVHLRARIEELLSIIDVLPFEGPADMHY
ARIRNELEAAGKTIGPNDLLIAAHACATGTVLVTDNMKEFNRVPGLQIENWL

Download         Length: 399 bp

>T227063 NZ_CP122685:c4363773-4363486 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9068.44 Da        Isoelectric Point: 4.4929

>AT227063 WP_113096531.1 NZ_CP088273:2038555-2038791 [Phyllobacterium sp. T1293]
MQERQVKLFRNGRNQAVRIPVEFEMPGDTAIMHREGNRLIIEPVKQRSLIEFLANLEPLADEFPDVDEGLLPLREIDL

Download         Length: 237 bp

>AT227063 NZ_CP122685:c4363499-4363197 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References