Detailed information of TA system TA227062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1880528..1881014
• Replicon: chromosome
• Accession: NZ_CP088273
• Organism: Phyllobacterium sp. T1293

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: LLE53_RS09280
• Protein ID: WP_234528045.1
• Coordinates: 1880528..1880746 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LLE53_RS09285
• Protein ID: WP_227986990.1
• Coordinates: 1880781..1881014 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLE53_RS09270 (LLE53_009270)	1876434..1877348	-	915	WP_112523331.1	DMT family transporter	-
LLE53_RS09275 (LLE53_009275)	1877640..1880285	+	2646	WP_227986988.1	aminopeptidase N	-
LLE53_RS09280 (LLE53_009280)	1880528..1880746	-	219	WP_234528045.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LLE53_RS09285 (LLE53_009285)	1880781..1881014	-	234	WP_227986990.1	DUF6290 family protein	Antitoxin
LLE53_RS09290 (LLE53_009290)	1881502..1883847	+	2346	WP_112523253.1	PAS domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-71)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8360.76 Da
• Isoelectric Point: 10.1590

>T227062 WP_234528045.1 NZ_CP088273:c1880746-1880528 [Phyllobacterium sp. T1293]
MGETEARRIMAFLGTRIALLDDPRQTGKTLRGATLGSLWRYRVGDYRIICEIQDQKLVVLVIDIGHRREVYR

Nucleotide

• Length: 219 bp

>T227062 NZ_CP122685:c3995107-3994709 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9074.10 Da
• Isoelectric Point: 4.2509

>AT227062 WP_227986990.1 NZ_CP088273:c1881014-1880781 [Phyllobacterium sp. T1293]
MSKQTAIRLPDEIYERLQALSSRTGRTTAYYIREALDEYLDDLEDVYLAEKVLERIRSGEEQTYSLEEVKQRLGLED

Nucleotide

• Length: 234 bp

>AT227062 NZ_CP122685:c3995403-3995110 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA