Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1708674..1709281 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LLE53_RS08395 Protein ID WP_227986901.1
Coordinates 1708976..1709281 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LLE53_RS08390 Protein ID WP_227986900.1
Coordinates 1708674..1708979 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS08365 (LLE53_008365) 1704151..1704849 - 699 WP_162700431.1 DnaA regulatory inactivator HdaA -
LLE53_RS08370 (LLE53_008370) 1704871..1706046 - 1176 WP_182509719.1 AI-2E family transporter -
LLE53_RS08375 (LLE53_008375) 1706027..1706575 - 549 WP_112524190.1 CDP-alcohol phosphatidyltransferase family protein -
LLE53_RS08380 (LLE53_008380) 1706980..1708047 + 1068 WP_227988172.1 phosphoribosylformylglycinamidine cyclo-ligase -
LLE53_RS08385 (LLE53_008385) 1708044..1708667 + 624 WP_227986899.1 phosphoribosylglycinamide formyltransferase -
LLE53_RS08390 (LLE53_008390) 1708674..1708979 - 306 WP_227986900.1 putative addiction module antidote protein Antitoxin
LLE53_RS08395 (LLE53_008395) 1708976..1709281 - 306 WP_227986901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE53_RS08400 (LLE53_008400) 1709363..1711474 - 2112 WP_227986902.1 molybdopterin oxidoreductase family protein -
LLE53_RS08405 (LLE53_008405) 1711642..1712289 + 648 WP_227986903.1 glutathione S-transferase family protein -
LLE53_RS08410 (LLE53_008410) 1712293..1713135 - 843 WP_227986904.1 EamA family transporter -
LLE53_RS08415 (LLE53_008415) 1713238..1713768 - 531 WP_227986905.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11539.41 Da        Isoelectric Point: 10.2181

>T227061 WP_227986901.1 NZ_CP088273:c1709281-1708976 [Phyllobacterium sp. T1293]
MRLIEKTDTFLSWIDGLRDQRARARIAMRLDRLIDGNLGDIKLVGDGVSELRIDYGPGYRVYFIERNDVLIILLCGGDKS
TQDRDIRKAKTMAAALRKVRS

Download         Length: 306 bp

>T227061 NZ_CP122685:c3975178-3974258 [Escherichia coli]
ATGGATCTGCGTGATAGTTATGCCCGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATATAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10726.31 Da        Isoelectric Point: 5.1051

>AT227061 WP_227986900.1 NZ_CP088273:c1708979-1708674 [Phyllobacterium sp. T1293]
MIKLSPYDTAQHLDSEEMIEEYLLATCEDGTPSEIARALGNIARARGITELAQKTGLTRQALYKALSGEGNPGLATITKV
ADVLGLKLSLVPVATKKQDAA

Download         Length: 306 bp

>AT227061 NZ_CP122685:c3975947-3975165 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAATACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGGCTTACCGTAGATGTAA
CGTCATTGACTACGGAACTAAAAATTGGCGACTGCCAGTTAGCAGGCAGTGTTCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References