Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 468123..468604 Replicon chromosome
Accession NZ_CP088273
Organism Phyllobacterium sp. T1293

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LLE53_RS02175 Protein ID WP_234528017.1
Coordinates 468123..468269 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LLE53_RS02180 Protein ID WP_112529112.1
Coordinates 468266..468604 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE53_RS02155 (LLE53_002155) 463236..464393 + 1158 WP_112529102.1 putative lipid II flippase FtsW -
LLE53_RS02160 (LLE53_002160) 464401..465528 + 1128 WP_227988022.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -
LLE53_RS02165 (LLE53_002165) 465525..466925 + 1401 WP_227988023.1 UDP-N-acetylmuramate--L-alanine ligase -
LLE53_RS02170 (LLE53_002170) 466982..467956 + 975 WP_112529108.1 UDP-N-acetylmuramate dehydrogenase -
LLE53_RS02175 (LLE53_002175) 468123..468269 + 147 WP_234528017.1 type II toxin-antitoxin system HicA family toxin Toxin
LLE53_RS02180 (LLE53_002180) 468266..468604 + 339 WP_112529112.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LLE53_RS02185 (LLE53_002185) 468822..469748 + 927 WP_227988025.1 D-alanine--D-alanine ligase -
LLE53_RS02190 (LLE53_002190) 469784..470677 + 894 WP_227988026.1 cell division protein FtsQ/DivIB -
LLE53_RS02195 (LLE53_002195) 470674..471996 + 1323 WP_227988027.1 cell division protein FtsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5381.11 Da        Isoelectric Point: 10.7161

>T227060 WP_234528017.1 NZ_CP088273:468123-468269 [Phyllobacterium sp. T1293]
VSEREGSRIGVFLFGEVRVFHRPHPSPDTDKGAVAAIRKWLESHGVRP

Download         Length: 147 bp

>T227060 NZ_CP122685:3771626-3771844 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12020.72 Da        Isoelectric Point: 4.6882

>AT227060 WP_112529112.1 NZ_CP088273:468266-468604 [Phyllobacterium sp. T1293]
MKNILDVDGHKAVISFDPELGLIRGEFLGLNGGADFYAQSVEGLLLEGRKSLQVFLEMCAEKGIAPFREFSGRFNVRLTA
DVHEAAVLAAAAENKSLNEWIAGAIEAATRAA

Download         Length: 339 bp

>AT227060 NZ_CP122685:3771226-3771600 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References