Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 146958..147628 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP088270 | ||
| Organism | Klebsiella pneumoniae strain CRKP-27 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LQ775_RS26865 | Protein ID | WP_004213072.1 |
| Coordinates | 146958..147401 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LQ775_RS26870 | Protein ID | WP_004213073.1 |
| Coordinates | 147398..147628 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ775_RS26830 (LQ775_26790) | 142367..142642 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LQ775_RS26835 (LQ775_26795) | 142705..143196 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LQ775_RS26840 (LQ775_26800) | 143245..144165 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LQ775_RS26845 (LQ775_26805) | 144256..144659 | + | 404 | Protein_153 | GAF domain-containing protein | - |
| LQ775_RS26850 (LQ775_26810) | 145177..145814 | - | 638 | Protein_154 | mucoid phenotype regulator RmpA2 | - |
| LQ775_RS26855 (LQ775_26815) | 146231..146535 | + | 305 | Protein_155 | transposase | - |
| LQ775_RS26860 (LQ775_26820) | 146558..146809 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| LQ775_RS26865 (LQ775_26825) | 146958..147401 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LQ775_RS26870 (LQ775_26830) | 147398..147628 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LQ775_RS26875 (LQ775_26835) | 148236..149369 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LQ775_RS26880 (LQ775_26840) | 149385..149678 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LQ775_RS26885 (LQ775_26845) | 149668..149874 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LQ775_RS26890 (LQ775_26850) | 150226..150516 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| LQ775_RS26895 (LQ775_26855) | 150506..151405 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
| LQ775_RS26900 (LQ775_26860) | 151454..152503 | - | 1050 | WP_227644306.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 | 1..209636 | 209636 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T227055 WP_004213072.1 NZ_CP088270:c147401-146958 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T227055 NZ_CP122685:c2608999-2608823 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAATGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAATGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT227055 WP_004213073.1 NZ_CP088270:c147628-147398 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT227055 NZ_CP122685:c2608777-2608361 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|