Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4819276..4819792 Replicon chromosome
Accession NZ_CP088269
Organism Klebsiella pneumoniae strain CRKP-27

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQ775_RS23415 Protein ID WP_009486548.1
Coordinates 4819276..4819560 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQ775_RS23420 Protein ID WP_002886901.1
Coordinates 4819550..4819792 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ775_RS23390 (4814672) 4814672..4814935 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LQ775_RS23395 (4815065) 4815065..4815238 + 174 WP_004222159.1 hypothetical protein -
LQ775_RS23400 (4815241) 4815241..4815984 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQ775_RS23405 (4816341) 4816341..4818479 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQ775_RS23410 (4818808) 4818808..4819272 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ775_RS23415 (4819276) 4819276..4819560 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ775_RS23420 (4819550) 4819550..4819792 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ775_RS23425 (4819870) 4819870..4821780 - 1911 WP_004152270.1 PRD domain-containing protein -
LQ775_RS23430 (4821803) 4821803..4822957 - 1155 WP_004178372.1 lactonase family protein -
LQ775_RS23435 (4823024) 4823024..4823764 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T227050 WP_009486548.1 NZ_CP088269:c4819560-4819276 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227050 NZ_CP122685:1967006-1967257 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227050 WP_002886901.1 NZ_CP088269:c4819792-4819550 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227050 NZ_CP122685:1967254-1967508 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References