Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4739923..4740626 | Replicon | chromosome |
| Accession | NZ_CP088269 | ||
| Organism | Klebsiella pneumoniae strain CRKP-27 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | - |
| Locus tag | LQ775_RS23070 | Protein ID | WP_094617794.1 |
| Coordinates | 4739923..4740264 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | LQ775_RS23075 | Protein ID | WP_094617792.1 |
| Coordinates | 4740285..4740626 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ775_RS23040 (4735134) | 4735134..4735808 | + | 675 | WP_004152211.1 | hypothetical protein | - |
| LQ775_RS23045 (4735810) | 4735810..4736157 | + | 348 | WP_004199257.1 | hypothetical protein | - |
| LQ775_RS23050 (4736160) | 4736160..4736639 | + | 480 | WP_002887049.1 | type VI secretion system tube protein TssD | - |
| LQ775_RS23055 (4736831) | 4736831..4737154 | - | 324 | Protein_4516 | hypothetical protein | - |
| LQ775_RS23060 (4737173) | 4737173..4738284 | - | 1112 | Protein_4517 | IS3 family transposase | - |
| LQ775_RS23065 (4738652) | 4738652..4739659 | - | 1008 | WP_049017154.1 | restriction endonuclease | - |
| LQ775_RS23070 (4739923) | 4739923..4740264 | - | 342 | WP_094617794.1 | TA system toxin CbtA family protein | Toxin |
| LQ775_RS23075 (4740285) | 4740285..4740626 | - | 342 | WP_094617792.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LQ775_RS23080 (4740637) | 4740637..4741179 | - | 543 | WP_087696572.1 | DNA repair protein RadC | - |
| LQ775_RS23085 (4741192) | 4741192..4741632 | - | 441 | WP_094617790.1 | antirestriction protein | - |
| LQ775_RS23090 (4741663) | 4741663..4742484 | - | 822 | WP_094617788.1 | DUF932 domain-containing protein | - |
| LQ775_RS23095 (4742604) | 4742604..4743077 | - | 474 | WP_094617786.1 | hypothetical protein | - |
| LQ775_RS23100 (4743149) | 4743149..4743601 | - | 453 | WP_087696570.1 | hypothetical protein | - |
| LQ775_RS23105 (4743637) | 4743637..4744353 | - | 717 | WP_087696569.1 | WYL domain-containing protein | - |
| LQ775_RS23110 (4744597) | 4744597..4745472 | - | 876 | WP_094617784.1 | GTPase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4735134..4764022 | 28888 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12753.65 Da Isoelectric Point: 8.0324
>T227049 WP_094617794.1 NZ_CP088269:c4740264-4739923 [Klebsiella pneumoniae]
MKTLPATNPQAATLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQTTGLLKRNRISAAR
MKTLPATNPQAATLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQTTGLLKRNRISAAR
Download Length: 342 bp
>T227049 NZ_CP122685:1136862-1137173 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12676.38 Da Isoelectric Point: 6.7300
>AT227049 WP_094617792.1 NZ_CP088269:c4740626-4740285 [Klebsiella pneumoniae]
MKSTDSESDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFNEAECLKLDAAFPHLICQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR
MKSTDSESDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFNEAECLKLDAAFPHLICQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR
Download Length: 342 bp
>AT227049 NZ_CP122685:1137170-1137589 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|