Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 847933..848590 Replicon chromosome
Accession NZ_CP088269
Organism Klebsiella pneumoniae strain CRKP-27

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQ775_RS04290 Protein ID WP_002916310.1
Coordinates 848180..848590 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQ775_RS04285 Protein ID WP_002916312.1
Coordinates 847933..848199 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ775_RS04260 (843089) 843089..844522 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LQ775_RS04265 (844641) 844641..845369 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQ775_RS04270 (845419) 845419..845730 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQ775_RS04275 (845894) 845894..846553 + 660 WP_002916317.1 hemolysin III family protein -
LQ775_RS04280 (846704) 846704..847687 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQ775_RS04285 (847933) 847933..848199 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQ775_RS04290 (848180) 848180..848590 + 411 WP_002916310.1 protein YgfX Toxin
LQ775_RS04295 (848597) 848597..849118 - 522 WP_002916308.1 flavodoxin FldB -
LQ775_RS04300 (849219) 849219..850115 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQ775_RS04305 (850138) 850138..850851 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ775_RS04310 (850857) 850857..852590 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227037 WP_002916310.1 NZ_CP088269:848180-848590 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227037 NZ_CP122681:2858077-2858184 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTTGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227037 WP_002916312.1 NZ_CP088269:847933-848199 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227037 NZ_CP122681:c2858030-2857964 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References