Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 732880..733516 Replicon chromosome
Accession NZ_CP088268
Organism Metabacillus litoralis strain NCTR108

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag KDJ21_RS03655 Protein ID WP_026562078.1
Coordinates 732880..733230 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KDJ21_RS03660 Protein ID WP_098797598.1
Coordinates 733235..733516 (-) Length 94 a.a.

Genomic Context

KDJ21_RS03680KDJ21_RS03620KDJ21_RS03625KDJ21_RS03630KDJ21_RS03635KDJ21_RS03640KDJ21_RS03645KDJ21_RS03650KDJ21_RS03655KDJ21_RS03660KDJ21_RS03665KDJ21_RS03670KDJ21_RS03675
Location: 736996..737715 (720 bp)
Type: Others
Protein ID: WP_212138431.1
Location: 728279..729070 (792 bp)
Type: Others
Protein ID: WP_212138423.1
Location: 729036..729518 (483 bp)
Type: Others
Protein ID: WP_121664246.1
Location: 729515..729847 (333 bp)
Type: Others
Protein ID: WP_212138424.1
Location: 729903..730910 (1008 bp)
Type: Others
Protein ID: WP_212138425.1
Location: 730921..731321 (401 bp)
Type: Others
Protein ID: Protein_665
Location: 731325..731687 (363 bp)
Type: Others
Protein ID: WP_098797600.1
Location: 731691..732521 (831 bp)
Type: Others
Protein ID: WP_212138427.1
Location: 732880..733230 (351 bp)
Type: Toxin
Protein ID: WP_026562078.1
Location: 733235..733516 (282 bp)
Type: Antitoxin
Protein ID: WP_098797598.1
Location: 733843..734986 (1144 bp)
Type: Others
Protein ID: Protein_670
Location: 735264..736292 (1029 bp)
Type: Others
Protein ID: WP_232273699.1
Location: 736499..736864 (366 bp)
Type: Others
Protein ID: WP_212138430.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KDJ21_RS03620 (KDJ21_003620)728279..729070-792WP_212138423.1RNA polymerase sigma factor SigB-
KDJ21_RS03625 (KDJ21_003625)729036..729518-483WP_121664246.1anti-sigma B factor RsbW-
KDJ21_RS03630 (KDJ21_003630)729515..729847-333WP_212138424.1anti-sigma factor antagonist-
KDJ21_RS03635 (KDJ21_003635)729903..730910-1008WP_212138425.1PP2C family protein-serine/threonine phosphatase-
KDJ21_RS03640 (KDJ21_003640)730921..731321-401Protein_665anti-sigma regulatory factor-
KDJ21_RS03645 (KDJ21_003645)731325..731687-363WP_098797600.1STAS domain-containing protein-
KDJ21_RS03650 (KDJ21_003650)731691..732521-831WP_212138427.1STAS domain-containing protein-
KDJ21_RS03655 (KDJ21_003655)732880..733230-351WP_026562078.1type II toxin-antitoxin system endoribonuclease NdoAToxin
KDJ21_RS03660 (KDJ21_003660)733235..733516-282WP_098797598.1antitoxin endoaiAntitoxin
KDJ21_RS03665 (KDJ21_003665)733843..734986-1144Protein_670alanine racemase-
KDJ21_RS03670 (KDJ21_003670)735264..736292-1029WP_232273699.1outer membrane lipoprotein carrier protein LolA-
KDJ21_RS03675 (KDJ21_003675)736499..736864-366WP_212138430.1holo-ACP synthase-
KDJ21_RS03680 (KDJ21_003680)736996..737715+720WP_212138431.1rhomboid family intramembrane serine protease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T227034 WP_026562078.1 NZ_CP088268:c733230-732880 [Metabacillus litoralis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T227034 NZ_CP122681:2149212-2149315 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10598.08 Da        Isoelectric Point: 5.8851

>AT227034 WP_098797598.1 NZ_CP088268:c733516-733235 [Metabacillus litoralis]
VSESSATTEILIQLPQALVSELDVLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT227034 NZ_CP122681:c2149353-2149082 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M2PN83

Antitoxin

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Source
ID
Structure
No matching records found

References