Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3599919..3600618 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LRS40_RS18655 Protein ID WP_231312325.1
Coordinates 3600229..3600618 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LRS40_RS18650 Protein ID WP_231312324.1
Coordinates 3599919..3600236 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS18635 (LRS40_18635) 3596104..3597495 - 1392 WP_142489507.1 NarK family nitrate/nitrite MFS transporter -
LRS40_RS18640 (LRS40_18640) 3597694..3598269 - 576 WP_231312322.1 TetR family transcriptional regulator -
LRS40_RS18645 (LRS40_18645) 3598385..3599872 + 1488 WP_231312323.1 MFS transporter -
LRS40_RS18650 (LRS40_18650) 3599919..3600236 - 318 WP_231312324.1 helix-turn-helix domain-containing protein Antitoxin
LRS40_RS18655 (LRS40_18655) 3600229..3600618 - 390 WP_231312325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRS40_RS18660 (LRS40_18660) 3600785..3602011 - 1227 WP_231312326.1 Zn-dependent hydrolase -
LRS40_RS18665 (LRS40_18665) 3602008..3602490 - 483 WP_142489497.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
LRS40_RS18670 (LRS40_18670) 3602508..3603665 - 1158 WP_231312327.1 branched-chain amino acid ABC transporter substrate-binding protein -
LRS40_RS18675 (LRS40_18675) 3603694..3604413 - 720 WP_231312328.1 ABC transporter ATP-binding protein -
LRS40_RS18680 (LRS40_18680) 3604406..3605173 - 768 WP_156263792.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-90)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14610.76 Da        Isoelectric Point: 6.0931

>T227032 WP_231312325.1 NZ_CP088265:c3600618-3600229 [Leclercia sp. G3L]
MGIYLTPEFEAERKDARISNTILCKAANAIISGLHGDHLGKYTYKKRLALPAVSPRDGARAIVFFHDGANVYFFDMYLKS
HLSKKKGKELEDDEIDAYCRIAEDFIALTPVQIKRLVDDKELLEVTCDD

Download         Length: 390 bp

>T227032 NZ_CP122681:1947422-1947673 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11619.52 Da        Isoelectric Point: 10.4635

>AT227032 WP_231312324.1 NZ_CP088265:c3600236-3599919 [Leclercia sp. G3L]
MTERLKRIQGMAQRYNKLGVVKDETVASIDAAVAARNIPAVREMTGGEIKEVRARYNMSQAALAITTGMSVESVSKWERN
ESKPNKAALRIINIIDVKGPEVFMV

Download         Length: 318 bp

>AT227032 NZ_CP122681:1947670-1947924 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References