Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2906279..2906869 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LRS40_RS15195 Protein ID WP_142486330.1
Coordinates 2906537..2906869 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LRS40_RS15190 Protein ID WP_231311958.1
Coordinates 2906279..2906536 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS15170 (LRS40_15170) 2902772..2903728 + 957 WP_231311957.1 L,D-transpeptidase -
LRS40_RS15180 (LRS40_15180) 2904181..2905098 + 918 WP_142486333.1 nitrogen assimilation transcriptional regulator NAC -
LRS40_RS15185 (LRS40_15185) 2905195..2906145 + 951 WP_142486332.1 HTH-type transcriptional regulator Cbl -
LRS40_RS15190 (LRS40_15190) 2906279..2906536 + 258 WP_231311958.1 antitoxin Antitoxin
LRS40_RS15195 (LRS40_15195) 2906537..2906869 + 333 WP_142486330.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LRS40_RS15205 (LRS40_15205) 2907115..2907912 - 798 WP_156264165.1 DgsA anti-repressor MtfA -
LRS40_RS15215 (LRS40_15215) 2908259..2908984 - 726 WP_156264164.1 two-component system response regulator DcuR -
LRS40_RS15220 (LRS40_15220) 2908981..2910594 - 1614 WP_231311959.1 sensor histidine kinase -
LRS40_RS15225 (LRS40_15225) 2910728..2911801 - 1074 WP_231311960.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(5-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11813.77 Da        Isoelectric Point: 10.4752

>T227023 WP_142486330.1 NZ_CP088265:2906537-2906869 [Leclercia sp. G3L]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKAAFNHLTRLPVVVPVTTGGKFARTAGFAVSLDEAGSKTRGVIRCDQPRTI
DMGARHGIKLERVPDSVMNEVLAKLGALLT

Download         Length: 333 bp

>T227023 NZ_CP122679:c4318911-4318624 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9281.72 Da        Isoelectric Point: 4.2941

>AT227023 WP_231311958.1 NZ_CP088265:2906279-2906536 [Leclercia sp. G3L]
MYITRLKKVGGSVMLAVPPAILKTLDLQPDSEVSVTIDNGCLIVEPQKLPHYSLAELLAQCDPHAELSEEDREWVDAPAA
GKEIL

Download         Length: 258 bp

>AT227023 NZ_CP122679:c4318637-4318335 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References