Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2024359..2025019 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LRS40_RS11185 Protein ID WP_142487009.1
Coordinates 2024606..2025019 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag LRS40_RS11180 Protein ID WP_142487010.1
Coordinates 2024359..2024625 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS11155 (LRS40_11155) 2019512..2020945 - 1434 WP_142487014.1 6-phospho-beta-glucosidase -
LRS40_RS11160 (LRS40_11160) 2021059..2021790 - 732 WP_142490021.1 MurR/RpiR family transcriptional regulator -
LRS40_RS11165 (LRS40_11165) 2021842..2022153 + 312 WP_231313706.1 N(4)-acetylcytidine aminohydrolase -
LRS40_RS11170 (LRS40_11170) 2022319..2022978 + 660 WP_142487012.1 hemolysin III family protein -
LRS40_RS11175 (LRS40_11175) 2023073..2024053 - 981 WP_142487011.1 tRNA-modifying protein YgfZ -
LRS40_RS11180 (LRS40_11180) 2024359..2024625 + 267 WP_142487010.1 FAD assembly factor SdhE Antitoxin
LRS40_RS11185 (LRS40_11185) 2024606..2025019 + 414 WP_142487009.1 protein YgfX Toxin
LRS40_RS11190 (LRS40_11190) 2025023..2025544 - 522 WP_142487008.1 flavodoxin FldB -
LRS40_RS11195 (LRS40_11195) 2025646..2026542 + 897 WP_231313707.1 site-specific tyrosine recombinase XerD -
LRS40_RS11200 (LRS40_11200) 2026564..2027277 + 714 WP_156264581.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRS40_RS11205 (LRS40_11205) 2027283..2029016 + 1734 WP_231313708.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16203.99 Da        Isoelectric Point: 10.6531

>T227021 WP_142487009.1 NZ_CP088265:2024606-2025019 [Leclercia sp. G3L]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLMPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLHWQGS
EWEIVGTPWMLNAGMMLRLRKGDGKRYQHLWLAADSMDEGEWRDLRRMLSQQPTQGR

Download         Length: 414 bp

>T227021 NZ_CP122679:c3943911-3942991 [Escherichia coli]
ATGGATCTGCGTGATAGTTATGCCCGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATATAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.02 Da        Isoelectric Point: 4.5242

>AT227021 WP_142487010.1 NZ_CP088265:2024359-2024625 [Leclercia sp. G3L]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227021 NZ_CP122679:c3944680-3943898 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAATACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGGCTTACCGTAGATGTAA
CGTCATTGACTACGGAACTAAAAATTGGCGACTGCCAGTTAGCAGGCAGTGTTCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References