Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 610882..611918 | Replicon | chromosome |
| Accession | NZ_CP088265 | ||
| Organism | Leclercia sp. G3L | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | LRS40_RS04330 | Protein ID | WP_142488063.1 |
| Coordinates | 611343..611918 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | LRS40_RS04325 | Protein ID | WP_106995644.1 |
| Coordinates | 610882..611343 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRS40_RS04295 (LRS40_04295) | 606536..607657 | - | 1122 | WP_231313178.1 | cupin domain-containing protein | - |
| LRS40_RS04300 (LRS40_04300) | 607864..608160 | + | 297 | WP_231313179.1 | SH3 domain-containing protein | - |
| LRS40_RS04305 (LRS40_04305) | 608157..608927 | - | 771 | WP_156262814.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LRS40_RS04310 (LRS40_04310) | 609026..609184 | + | 159 | WP_156262813.1 | hypothetical protein | - |
| LRS40_RS04315 (LRS40_04315) | 609181..610338 | + | 1158 | WP_231313180.1 | MFS transporter | - |
| LRS40_RS04320 (LRS40_04320) | 610340..610726 | + | 387 | WP_231313181.1 | VOC family protein | - |
| LRS40_RS04325 (LRS40_04325) | 610882..611343 | + | 462 | WP_106995644.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LRS40_RS04330 (LRS40_04330) | 611343..611918 | + | 576 | WP_142488063.1 | PIN domain-containing protein | Toxin |
| LRS40_RS04335 (LRS40_04335) | 612208..612807 | + | 600 | WP_231313183.1 | response regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21747.96 Da Isoelectric Point: 4.8643
>T227017 WP_142488063.1 NZ_CP088265:611343-611918 [Leclercia sp. G3L]
MTHSPYPVVLDACVLYPSMLRDLLMHIGKTGLYQPKWTTQIHDEWQRNLLINRPDITADQLKRTEMLMNKAFGDACVSGY
ESIIDGLSLPDQDDRHVLAAAIRSDSEVIVTYNLVDFPGGNLAEFDVEALHPDEFLSDLFDLNHALVLEAVRMQRSHLRH
PPLNPDQFLQGLLQLGLPKTVTELEKYRVMI
MTHSPYPVVLDACVLYPSMLRDLLMHIGKTGLYQPKWTTQIHDEWQRNLLINRPDITADQLKRTEMLMNKAFGDACVSGY
ESIIDGLSLPDQDDRHVLAAAIRSDSEVIVTYNLVDFPGGNLAEFDVEALHPDEFLSDLFDLNHALVLEAVRMQRSHLRH
PPLNPDQFLQGLLQLGLPKTVTELEKYRVMI
Download Length: 576 bp
>T227017 NZ_CP122679:2881840-2881947 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17085.59 Da Isoelectric Point: 6.3368
>AT227017 WP_106995644.1 NZ_CP088265:610882-611343 [Leclercia sp. G3L]
MTNSLLNSLTLPAPKEIEAAVRGQRELATFLSTKQETQKITIQDAQDVTHQIELPTSSLTLLMSILGELAAGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRILFADLMKYKDQRDAESIQALRELAEQSQELGFY
MTNSLLNSLTLPAPKEIEAAVRGQRELATFLSTKQETQKITIQDAQDVTHQIELPTSSLTLLMSILGELAAGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRILFADLMKYKDQRDAESIQALRELAEQSQELGFY
Download Length: 462 bp
>AT227017 NZ_CP122679:c2881790-2881727 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|