Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 590572..591366 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LRS40_RS04220 Protein ID WP_231313860.1
Coordinates 590866..591366 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag LRS40_RS04215 Protein ID WP_142488082.1
Coordinates 590572..590841 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS04180 (LRS40_04180) 586530..586997 - 468 WP_231313164.1 MarR family transcriptional regulator -
LRS40_RS04185 (LRS40_04185) 587113..587454 - 342 WP_142488088.1 hypothetical protein -
LRS40_RS04190 (LRS40_04190) 587472..588035 - 564 WP_231313165.1 LuxR C-terminal-related transcriptional regulator -
LRS40_RS04195 (LRS40_04195) 588343..588732 - 390 WP_231313166.1 hypothetical protein -
LRS40_RS04200 (LRS40_04200) 589028..589723 - 696 WP_231313167.1 winged helix-turn-helix domain-containing protein -
LRS40_RS04205 (LRS40_04205) 589698..590093 - 396 WP_142488084.1 amino acid-binding protein -
LRS40_RS04210 (LRS40_04210) 590086..590409 - 324 WP_231313168.1 antibiotic biosynthesis monooxygenase -
LRS40_RS04215 (LRS40_04215) 590572..590841 + 270 WP_142488082.1 DUF1778 domain-containing protein Antitoxin
LRS40_RS04220 (LRS40_04220) 590866..591366 + 501 WP_231313860.1 GNAT family N-acetyltransferase Toxin
LRS40_RS04225 (LRS40_04225) 591455..592870 - 1416 WP_231313169.1 aldehyde dehydrogenase family protein -
LRS40_RS04230 (LRS40_04230) 592971..593873 + 903 WP_231313170.1 LysR family transcriptional regulator -
LRS40_RS04235 (LRS40_04235) 593860..594339 - 480 WP_231313171.1 carboxymuconolactone decarboxylase family protein -
LRS40_RS04240 (LRS40_04240) 594440..595831 + 1392 WP_231313172.1 PLP-dependent aminotransferase family protein -
LRS40_RS04245 (LRS40_04245) 595947..596201 + 255 WP_142488077.1 DUF4282 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18575.34 Da        Isoelectric Point: 7.3982

>T227016 WP_231313860.1 NZ_CP088265:590866-591366 [Leclercia sp. G3L]
MFSQTTHYDLTGFNCGEDTLNRFLCEHLARQHVGRLLRAYLLVTDDPTPKVLGYYTLSGSCFEKETLPSKTQQRKVPYVN
VPSVTLGRLAIHQDLQGQGWGMTLVTHSMKVVWLASQAVGIHGMFVDALNDKAKDFYLTLGFIPLTGSNADALFYPTKSI
EKLFAE

Download         Length: 501 bp

>T227016 NZ_CP122679:2881305-2881412 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTTGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10415.85 Da        Isoelectric Point: 5.2171

>AT227016 WP_142488082.1 NZ_CP088265:590572-590841 [Leclercia sp. G3L]
MPALKKQRIDLRLTDEDKDLIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLILNEDSWKRVMDALDNPPEPNERLKR
AARRLQNME

Download         Length: 270 bp

>AT227016 NZ_CP122679:c2881258-2881192 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References