Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 81254..81891 | Replicon | plasmid pG3L-1 |
Accession | NZ_CP088263 | ||
Organism | Leclercia sp. G3L |
Toxin (Protein)
Gene name | vagD | Uniprot ID | - |
Locus tag | LRS40_RS00440 | Protein ID | WP_231311750.1 |
Coordinates | 81254..81664 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | - |
Locus tag | LRS40_RS00445 | Protein ID | WP_231311751.1 |
Coordinates | 81661..81891 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LRS40_RS00425 (LRS40_00425) | 76898..78325 | - | 1428 | WP_231311747.1 | phosphotransferase | - |
LRS40_RS00430 (LRS40_00430) | 78306..79232 | - | 927 | WP_231311748.1 | hypothetical protein | - |
LRS40_RS00435 (LRS40_00435) | 79229..81067 | - | 1839 | WP_231311749.1 | AAA family ATPase | - |
LRS40_RS00440 (LRS40_00440) | 81254..81664 | - | 411 | WP_231311750.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LRS40_RS00445 (LRS40_00445) | 81661..81891 | - | 231 | WP_231311751.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LRS40_RS00450 (LRS40_00450) | 82493..82843 | + | 351 | WP_000493378.1 | hypothetical protein | - |
LRS40_RS00455 (LRS40_00455) | 82894..83637 | + | 744 | WP_000129823.1 | hypothetical protein | - |
LRS40_RS00460 (LRS40_00460) | 83634..84410 | + | 777 | WP_000015958.1 | site-specific integrase | - |
LRS40_RS00465 (LRS40_00465) | 84468..84725 | - | 258 | WP_000764642.1 | hypothetical protein | - |
LRS40_RS00470 (LRS40_00470) | 84854..84958 | - | 105 | WP_032409716.1 | hypothetical protein | - |
LRS40_RS00475 (LRS40_00475) | 85488..86354 | + | 867 | WP_004118283.1 | replication initiation protein | - |
LRS40_RS00480 (LRS40_00480) | 86531..86800 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | ant(3'')-Ia / blaTEM-1B / qnrS1 / floR / blaLAP-2 / tet(A) / dfrA1 / qacE / sul1 / tet(X4) / lnu(G) | - | 1..253593 | 253593 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14146.38 Da Isoelectric Point: 4.8484
>T227013 WP_231311750.1 NZ_CP088263:c81664-81254 [Leclercia sp. G3L]
VKKTYMLDTGICALILREQPAALLKRLEQAVLDGDRIVVSAITWAEISLAARASGPATQQLADAFAARLDAILPWDRAAV
DATTDVKVALRLAGTPIGLNDTAIAGHAIAAGAVLVTGKGGEFERVPGLTLEECLS
VKKTYMLDTGICALILREQPAALLKRLEQAVLDGDRIVVSAITWAEISLAARASGPATQQLADAFAARLDAILPWDRAAV
DATTDVKVALRLAGTPIGLNDTAIAGHAIAAGAVLVTGKGGEFERVPGLTLEECLS
Download Length: 411 bp
>T227013 NZ_CP122679:2495896-2496183 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8769.89 Da Isoelectric Point: 4.3775
>AT227013 WP_231311751.1 NZ_CP088263:c81891-81661 [Leclercia sp. G3L]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQMEKADPDFMAEREDVISDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQMEKADPDFMAEREDVISDEGRFEL
Download Length: 231 bp
>AT227013 NZ_CP122679:2495657-2495896 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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