Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 81254..81891 Replicon plasmid pG3L-1
Accession NZ_CP088263
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LRS40_RS00440 Protein ID WP_231311750.1
Coordinates 81254..81664 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LRS40_RS00445 Protein ID WP_231311751.1
Coordinates 81661..81891 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS00425 (LRS40_00425) 76898..78325 - 1428 WP_231311747.1 phosphotransferase -
LRS40_RS00430 (LRS40_00430) 78306..79232 - 927 WP_231311748.1 hypothetical protein -
LRS40_RS00435 (LRS40_00435) 79229..81067 - 1839 WP_231311749.1 AAA family ATPase -
LRS40_RS00440 (LRS40_00440) 81254..81664 - 411 WP_231311750.1 type II toxin-antitoxin system VapC family toxin Toxin
LRS40_RS00445 (LRS40_00445) 81661..81891 - 231 WP_231311751.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRS40_RS00450 (LRS40_00450) 82493..82843 + 351 WP_000493378.1 hypothetical protein -
LRS40_RS00455 (LRS40_00455) 82894..83637 + 744 WP_000129823.1 hypothetical protein -
LRS40_RS00460 (LRS40_00460) 83634..84410 + 777 WP_000015958.1 site-specific integrase -
LRS40_RS00465 (LRS40_00465) 84468..84725 - 258 WP_000764642.1 hypothetical protein -
LRS40_RS00470 (LRS40_00470) 84854..84958 - 105 WP_032409716.1 hypothetical protein -
LRS40_RS00475 (LRS40_00475) 85488..86354 + 867 WP_004118283.1 replication initiation protein -
LRS40_RS00480 (LRS40_00480) 86531..86800 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / blaTEM-1B / qnrS1 / floR / blaLAP-2 / tet(A) / dfrA1 / qacE / sul1 / tet(X4) / lnu(G) - 1..253593 253593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-127)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14146.38 Da        Isoelectric Point: 4.8484

>T227013 WP_231311750.1 NZ_CP088263:c81664-81254 [Leclercia sp. G3L]
VKKTYMLDTGICALILREQPAALLKRLEQAVLDGDRIVVSAITWAEISLAARASGPATQQLADAFAARLDAILPWDRAAV
DATTDVKVALRLAGTPIGLNDTAIAGHAIAAGAVLVTGKGGEFERVPGLTLEECLS

Download         Length: 411 bp

>T227013 NZ_CP122679:2495896-2496183 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8769.89 Da        Isoelectric Point: 4.3775

>AT227013 WP_231311751.1 NZ_CP088263:c81891-81661 [Leclercia sp. G3L]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQMEKADPDFMAEREDVISDEGRFEL

Download         Length: 231 bp

>AT227013 NZ_CP122679:2495657-2495896 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References