Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4639855..4640505 Replicon chromosome
Accession NZ_CP088247
Organism Methylorubrum sp. B1-46

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LPC10_RS21570 Protein ID WP_231344297.1
Coordinates 4640251..4640505 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LPC10_RS21565 Protein ID WP_231344296.1
Coordinates 4639855..4640229 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC10_RS21545 (LPC10_21540) 4635613..4636143 - 531 WP_231344293.1 GNAT family N-acetyltransferase -
LPC10_RS21550 (LPC10_21545) 4636321..4636758 + 438 WP_231344294.1 DUF983 domain-containing protein -
LPC10_RS21555 (LPC10_21550) 4636840..4638582 - 1743 WP_231344295.1 L-lactate permease -
LPC10_RS21560 (LPC10_21555) 4638884..4639807 + 924 WP_133089695.1 manganese catalase family protein -
LPC10_RS21565 (LPC10_21560) 4639855..4640229 - 375 WP_231344296.1 helix-turn-helix transcriptional regulator Antitoxin
LPC10_RS21570 (LPC10_21565) 4640251..4640505 - 255 WP_231344297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPC10_RS21575 (LPC10_21570) 4640596..4641492 - 897 WP_231344298.1 phytoene/squalene synthase family protein -
LPC10_RS21580 (LPC10_21575) 4641521..4641919 - 399 WP_231344299.1 MTH938/NDUFAF3 family protein -
LPC10_RS21585 (LPC10_21580) 4642021..4642962 - 942 WP_108941930.1 protein translocase subunit SecF -
LPC10_RS21590 (LPC10_21585) 4643069..4644670 - 1602 WP_108941931.1 protein translocase subunit SecD -
LPC10_RS21595 (LPC10_21590) 4644735..4645067 - 333 WP_108941932.1 preprotein translocase subunit YajC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(71-122)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9244.81 Da        Isoelectric Point: 10.0342

>T227009 WP_231344297.1 NZ_CP088247:c4640505-4640251 [Methylorubrum sp. B1-46]
MAEVVYSKAAVQALIRLPADVSRKIRLKIEQYAADPASLANNVKALRGEPGILRLRVGDWRVLFTEEGVVIAVIRIAPRG
DAYD

Download         Length: 255 bp

>T227009 NZ_CP122679:1134877-1135188 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13261.99 Da        Isoelectric Point: 4.9669

>AT227009 WP_231344296.1 NZ_CP088247:c4640229-4639855 [Methylorubrum sp. B1-46]
MNTRIITTPGGERLVLMPESDFEALVAAAEDNADRTAVAEFRRKIAAGEEELVPASVVERLLSGENRVRVWREHRGLSGA
ALAKQAGLAQAYLSQIETGAREGTIETYGKLAGALRVSLNDLAG

Download         Length: 375 bp

>AT227009 NZ_CP122679:1135185-1135604 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References