Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 801155..801834 Replicon chromosome
Accession NZ_CP088247
Organism Methylorubrum sp. B1-46

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPC10_RS03900 Protein ID WP_231345542.1
Coordinates 801409..801834 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPC10_RS03895 Protein ID WP_231345541.1
Coordinates 801155..801412 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC10_RS03875 (LPC10_03875) 796853..798244 + 1392 WP_231345537.1 hypothetical protein -
LPC10_RS03880 (LPC10_03880) 798241..798756 + 516 WP_231345538.1 hypothetical protein -
LPC10_RS03885 (LPC10_03885) 798791..799990 + 1200 WP_231345539.1 hypothetical protein -
LPC10_RS03890 (LPC10_03890) 800072..801076 + 1005 WP_231345540.1 serine protease -
LPC10_RS03895 (LPC10_03895) 801155..801412 + 258 WP_231345541.1 Arc family DNA-binding protein Antitoxin
LPC10_RS03900 (LPC10_03900) 801409..801834 + 426 WP_231345542.1 type II toxin-antitoxin system VapC family toxin Toxin
LPC10_RS03905 (LPC10_03905) 801971..802810 + 840 WP_231345543.1 OmpA family protein -
LPC10_RS03910 (LPC10_03910) 802861..803835 + 975 WP_231345544.1 hypothetical protein -
LPC10_RS03915 (LPC10_03915) 803842..804195 + 354 WP_231345545.1 hypothetical protein -
LPC10_RS03920 (LPC10_03920) 804192..805193 + 1002 WP_231345546.1 hypothetical protein -
LPC10_RS25530 805218..805346 - 129 WP_255700732.1 hypothetical protein -
LPC10_RS03925 (LPC10_03925) 805384..806148 + 765 WP_231345547.1 hypothetical protein -
LPC10_RS03930 (LPC10_03930) 806231..806656 + 426 WP_231345548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-45)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15200.49 Da        Isoelectric Point: 7.0158

>T227008 WP_231345542.1 NZ_CP088247:801409-801834 [Methylorubrum sp. B1-46]
VIVLDTNVLSELWRATPDPGVLTWVDAQAVETLYLTAVTVAELRFGLATMPADKRRDIFRDRLEREVLPAFAGRVLPFDL
DASRHYAAFMARARAAGKAIGMADGTIAATAAVRGFIVATRDTGPFEATGIGVINPWRTAG

Download         Length: 426 bp

>T227008 NZ_CP122679:910116-910523 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9342.61 Da        Isoelectric Point: 9.0129

>AT227008 WP_231345541.1 NZ_CP088247:801155-801412 [Methylorubrum sp. B1-46]
MASITIRNVPDEVHRALRIRAAQHGRSTEAEIRAILEQAAKPAGRMKLGSLLSSIARDAGGLTEAEADAFDRFRDRAPAE
PMRFE

Download         Length: 258 bp

>AT227008 NZ_CP122679:909869-910135 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References