Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 227659..229394 | Replicon | chromosome |
| Accession | NZ_CP088247 | ||
| Organism | Methylorubrum sp. B1-46 | ||
Toxin (Protein)
| Gene name | HipA3 | Uniprot ID | - |
| Locus tag | LPC10_RS01205 | Protein ID | WP_063987395.1 |
| Coordinates | 227659..228972 (-) | Length | 438 a.a. |
Antitoxin (Protein)
| Gene name | HipB3 | Uniprot ID | - |
| Locus tag | LPC10_RS01210 | Protein ID | WP_063987372.1 |
| Coordinates | 228969..229394 (-) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPC10_RS01180 (LPC10_01185) | 223377..223592 | + | 216 | Protein_234 | transposase | - |
| LPC10_RS01185 (LPC10_01190) | 223597..224052 | - | 456 | WP_063987368.1 | cupin domain-containing protein | - |
| LPC10_RS01190 (LPC10_01195) | 224049..225023 | - | 975 | WP_231345091.1 | alpha/beta fold hydrolase | - |
| LPC10_RS01195 (LPC10_01200) | 225023..226210 | - | 1188 | WP_231345092.1 | MFS transporter | - |
| LPC10_RS01200 (LPC10_01205) | 226394..227332 | - | 939 | WP_063987371.1 | LysR substrate-binding domain-containing protein | - |
| LPC10_RS01205 (LPC10_01210) | 227659..228972 | - | 1314 | WP_063987395.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LPC10_RS01210 (LPC10_01215) | 228969..229394 | - | 426 | WP_063987372.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LPC10_RS01215 (LPC10_01220) | 229847..229927 | - | 81 | WP_231346937.1 | hypothetical protein | - |
| LPC10_RS01220 (LPC10_01225) | 230084..230392 | - | 309 | WP_131801314.1 | hypothetical protein | - |
| LPC10_RS01225 (LPC10_01230) | 230588..230773 | + | 186 | WP_231345093.1 | ATPase, T2SS/T4P/T4SS family | - |
| LPC10_RS01230 (LPC10_01235) | 231309..231965 | + | 657 | WP_231345094.1 | hypothetical protein | - |
| LPC10_RS01235 (LPC10_01240) | 231933..233099 | - | 1167 | WP_131801306.1 | hypothetical protein | - |
| LPC10_RS01240 (LPC10_01245) | 233102..234136 | - | 1035 | WP_063987224.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 438 a.a. Molecular weight: 47915.87 Da Isoelectric Point: 5.4861
>T227007 WP_063987395.1 NZ_CP088247:c228972-227659 [Methylorubrum sp. B1-46]
VTVATVRLWGTDIGAVSLDAQGGVAAFQYDPDFVAAPIDVELSPFKMPRGEAPFSFPELDRKAFHGLPGMLADSLPDKYG
NAVIDAWLASQGRAPESFDAVERLCYIGTRGMGALEFAPVKGPSSGKSQTVHLDALVQLASDVLSNRAALAQSFAEGSRE
AALREILLIGTSAGGARAKAVIAWNPDTNEVRSGQAVAEPGFGYWLLKFDGVAGNGDKDLRDPQGYGAIEYAYSLMAQAA
GVAMGDTRILEENGRRHFMTRRFDREDGGGKLHMQSLAALAHLDFNQPRTHSYDQAFLAIRQLDLGMDAVEEQFRRMAFN
VVGRNQDDHVKNIAFLMDRDGTWSLSPAYDITWSYNPLGDWTSKHQMSVNGKWDGFAVEDFRETGRRVSLRRGRAVAIFD
EVVQAVRRWPEFAAEAGVSDFHREQVAKSLRLALPDK
VTVATVRLWGTDIGAVSLDAQGGVAAFQYDPDFVAAPIDVELSPFKMPRGEAPFSFPELDRKAFHGLPGMLADSLPDKYG
NAVIDAWLASQGRAPESFDAVERLCYIGTRGMGALEFAPVKGPSSGKSQTVHLDALVQLASDVLSNRAALAQSFAEGSRE
AALREILLIGTSAGGARAKAVIAWNPDTNEVRSGQAVAEPGFGYWLLKFDGVAGNGDKDLRDPQGYGAIEYAYSLMAQAA
GVAMGDTRILEENGRRHFMTRRFDREDGGGKLHMQSLAALAHLDFNQPRTHSYDQAFLAIRQLDLGMDAVEEQFRRMAFN
VVGRNQDDHVKNIAFLMDRDGTWSLSPAYDITWSYNPLGDWTSKHQMSVNGKWDGFAVEDFRETGRRVSLRRGRAVAIFD
EVVQAVRRWPEFAAEAGVSDFHREQVAKSLRLALPDK
Download Length: 1314 bp
>T227007 NZ_CP122679:c827566-827189 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 142 a.a. Molecular weight: 14958.12 Da Isoelectric Point: 11.8607
>AT227007 WP_063987372.1 NZ_CP088247:c229394-228969 [Methylorubrum sp. B1-46]
MHLSPLLTDDATLGEIGNRFMQRRLQRNLTQAELAARAGVSKRTIERLEEGGSSQFANVVKVIRALDLFDGLDRLVPEVG
PSPIQQAKLQGRQRKRASGTAAKAVAKGGAAAVGAGKPRVASRTKTAAKGSGKAWSWGDAR
MHLSPLLTDDATLGEIGNRFMQRRLQRNLTQAELAARAGVSKRTIERLEEGGSSQFANVVKVIRALDLFDGLDRLVPEVG
PSPIQQAKLQGRQRKRASGTAAKAVAKGGAAAVGAGKPRVASRTKTAAKGSGKAWSWGDAR
Download Length: 426 bp
>AT227007 NZ_CP122679:c828024-827656 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|