Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 221162..221968 Replicon chromosome
Accession NZ_CP088247
Organism Methylorubrum sp. B1-46

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LPC10_RS01170 Protein ID WP_063987365.1
Coordinates 221465..221968 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LPC10_RS01165 Protein ID WP_063987364.1
Coordinates 221162..221461 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC10_RS01145 (LPC10_01150) 216616..217851 - 1236 WP_231345090.1 TerD family protein -
LPC10_RS01150 (LPC10_01155) 218060..219559 + 1500 WP_012778770.1 IS21-like element ISMdi7 family transposase -
LPC10_RS01155 (LPC10_01160) 219556..220398 + 843 WP_003596510.1 IS21-like element ISMdi7 family helper ATPase IstB -
LPC10_RS01160 (LPC10_01165) 220535..220957 - 423 Protein_230 transposase -
LPC10_RS01165 (LPC10_01170) 221162..221461 + 300 WP_063987364.1 DUF1778 domain-containing protein Antitoxin
LPC10_RS01170 (LPC10_01175) 221465..221968 + 504 WP_063987365.1 GNAT family N-acetyltransferase Toxin
LPC10_RS01175 (LPC10_01180) 221976..222800 + 825 WP_063987366.1 hypothetical protein -
LPC10_RS01180 (LPC10_01185) 223377..223592 + 216 Protein_234 transposase -
LPC10_RS01185 (LPC10_01190) 223597..224052 - 456 WP_063987368.1 cupin domain-containing protein -
LPC10_RS01190 (LPC10_01195) 224049..225023 - 975 WP_231345091.1 alpha/beta fold hydrolase -
LPC10_RS01195 (LPC10_01200) 225023..226210 - 1188 WP_231345092.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-92)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 17605.30 Da        Isoelectric Point: 7.8301

>T227006 WP_063987365.1 NZ_CP088247:221465-221968 [Methylorubrum sp. B1-46]
VPLSAPEPITAAHDVSQFSCGKPTLDHWLKTRALSNQTKGFTAVLVVHEAGRVVGYYGLAPTAVVPAVLPRAVRTGQPPD
PVPCLLLGQLATDEAWVGQGIGTGLVKHALQRCVQAASLVGGRALMVNAIDDDAAQFWQRRGFLPTHDDPLVLFRSIAAI
AASLTQA

Download         Length: 504 bp

>T227006 NZ_CP122679:c616805-616341 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATAGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11026.82 Da        Isoelectric Point: 8.5610

>AT227006 WP_063987364.1 NZ_CP088247:221162-221461 [Methylorubrum sp. B1-46]
MASTAERKEYPISMRLPESDVAMIDRAATLRGRSRTDFVRDAAVRAAEEVVMEQSFIRMSPEGFAGFMEVLAAPAMPVPA
MVKLAKRPAPWEPGYEPKR

Download         Length: 300 bp

>AT227006 NZ_CP122679:c617140-616805 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References