Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 216593..217229 Replicon chromosome
Accession NZ_CP088245
Organism Metabacillus sp. B2-18

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag LPC09_RS01195 Protein ID WP_026562078.1
Coordinates 216879..217229 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LPC09_RS01190 Protein ID WP_098797598.1
Coordinates 216593..216874 (+) Length 94 a.a.

Genomic Context

LPC09_RS01175LPC09_RS01180LPC09_RS01185LPC09_RS01190LPC09_RS01195LPC09_RS01200LPC09_RS01205LPC09_RS01210LPC09_RS01215LPC09_RS01220LPC09_RS01225LPC09_RS01230LPC09_RS01170
Location: 213251..213616 (366 bp)
Type: Others
Protein ID: WP_098797595.1
Location: 213833..214852 (1020 bp)
Type: Others
Protein ID: WP_269217413.1
Location: 215119..216264 (1146 bp)
Type: Others
Protein ID: WP_231308823.1
Location: 216593..216874 (282 bp)
Type: Antitoxin
Protein ID: WP_098797598.1
Location: 216879..217229 (351 bp)
Type: Toxin
Protein ID: WP_026562078.1
Location: 217565..218407 (843 bp)
Type: Others
Protein ID: WP_231308824.1
Location: 218407..218769 (363 bp)
Type: Others
Protein ID: WP_098797600.1
Location: 218773..219174 (402 bp)
Type: Others
Protein ID: WP_098797601.1
Location: 219185..220192 (1008 bp)
Type: Others
Protein ID: WP_098797602.1
Location: 220248..220580 (333 bp)
Type: Others
Protein ID: WP_098797603.1
Location: 220577..221059 (483 bp)
Type: Others
Protein ID: WP_098797604.1
Location: 221025..221816 (792 bp)
Type: Others
Protein ID: WP_098797605.1
Location: 212398..213117 (720 bp)
Type: Others
Protein ID: WP_098797594.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LPC09_RS01170 (LPC09_01170)212398..213117-720WP_098797594.1rhomboid family intramembrane serine protease-
LPC09_RS01175 (LPC09_01175)213251..213616+366WP_098797595.1holo-ACP synthase-
LPC09_RS01180 (LPC09_01180)213833..214852+1020WP_269217413.1outer membrane lipoprotein carrier protein LolA-
LPC09_RS01185 (LPC09_01185)215119..216264+1146WP_231308823.1alanine racemase-
LPC09_RS01190 (LPC09_01190)216593..216874+282WP_098797598.1antitoxin endoaiAntitoxin
LPC09_RS01195 (LPC09_01195)216879..217229+351WP_026562078.1type II toxin-antitoxin system endoribonuclease NdoAToxin
LPC09_RS01200 (LPC09_01200)217565..218407+843WP_231308824.1STAS domain-containing protein-
LPC09_RS01205 (LPC09_01205)218407..218769+363WP_098797600.1STAS domain-containing protein-
LPC09_RS01210 (LPC09_01210)218773..219174+402WP_098797601.1anti-sigma regulatory factor-
LPC09_RS01215 (LPC09_01215)219185..220192+1008WP_098797602.1PP2C family protein-serine/threonine phosphatase-
LPC09_RS01220 (LPC09_01220)220248..220580+333WP_098797603.1anti-sigma factor antagonist-
LPC09_RS01225 (LPC09_01225)220577..221059+483WP_098797604.1anti-sigma B factor RsbW-
LPC09_RS01230 (LPC09_01230)221025..221816+792WP_098797605.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T227005 WP_026562078.1 NZ_CP088245:216879-217229 [Metabacillus sp. B2-18]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T227005 NZ_CP122678:c94810-94658 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10598.08 Da        Isoelectric Point: 5.8851

>AT227005 WP_098797598.1 NZ_CP088245:216593-216874 [Metabacillus sp. B2-18]
VSESSATTEILIQLPQALVSELDVLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT227005 NZ_CP122678:94865-94922 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M2PN83

Antitoxin

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Source
ID
Structure
No matching records found

References