Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 216593..217229 Replicon chromosome
Accession NZ_CP088245
Organism Metabacillus sp. B2-18

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag LPC09_RS01195 Protein ID WP_026562078.1
Coordinates 216879..217229 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LPC09_RS01190 Protein ID WP_098797598.1
Coordinates 216593..216874 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC09_RS01170 (LPC09_01170) 212398..213117 - 720 WP_098797594.1 rhomboid family intramembrane serine protease -
LPC09_RS01175 (LPC09_01175) 213251..213616 + 366 WP_098797595.1 holo-ACP synthase -
LPC09_RS01180 (LPC09_01180) 213833..214852 + 1020 WP_269217413.1 outer membrane lipoprotein carrier protein LolA -
LPC09_RS01185 (LPC09_01185) 215119..216264 + 1146 WP_231308823.1 alanine racemase -
LPC09_RS01190 (LPC09_01190) 216593..216874 + 282 WP_098797598.1 antitoxin endoai Antitoxin
LPC09_RS01195 (LPC09_01195) 216879..217229 + 351 WP_026562078.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LPC09_RS01200 (LPC09_01200) 217565..218407 + 843 WP_231308824.1 STAS domain-containing protein -
LPC09_RS01205 (LPC09_01205) 218407..218769 + 363 WP_098797600.1 STAS domain-containing protein -
LPC09_RS01210 (LPC09_01210) 218773..219174 + 402 WP_098797601.1 anti-sigma regulatory factor -
LPC09_RS01215 (LPC09_01215) 219185..220192 + 1008 WP_098797602.1 PP2C family protein-serine/threonine phosphatase -
LPC09_RS01220 (LPC09_01220) 220248..220580 + 333 WP_098797603.1 anti-sigma factor antagonist -
LPC09_RS01225 (LPC09_01225) 220577..221059 + 483 WP_098797604.1 anti-sigma B factor RsbW -
LPC09_RS01230 (LPC09_01230) 221025..221816 + 792 WP_098797605.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T227005 WP_026562078.1 NZ_CP088245:216879-217229 [Metabacillus sp. B2-18]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T227005 NZ_CP122678:c94810-94658 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10598.08 Da        Isoelectric Point: 5.8851

>AT227005 WP_098797598.1 NZ_CP088245:216593-216874 [Metabacillus sp. B2-18]
VSESSATTEILIQLPQALVSELDVLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT227005 NZ_CP122678:94865-94922 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2PN83

Antitoxin

Source ID Structure

References