Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1808888..1809536 Replicon chromosome
Accession NZ_CP088241
Organism Stenotrophomonas maltophilia strain 2013-SM15

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LQ329_RS08450 Protein ID WP_005407702.1
Coordinates 1809231..1809536 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LQ329_RS08445 Protein ID WP_005407703.1
Coordinates 1808888..1809190 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ329_RS08410 (LQ329_08410) 1804328..1804549 - 222 WP_004153772.1 CsbD family protein -
LQ329_RS08415 (LQ329_08415) 1804757..1804894 - 138 WP_005407710.1 entericidin A/B family lipoprotein -
LQ329_RS08420 (LQ329_08420) 1805055..1805975 - 921 WP_005407709.1 arginase -
LQ329_RS08425 (LQ329_08425) 1806106..1806453 + 348 WP_005411961.1 hypothetical protein -
LQ329_RS08430 (LQ329_08430) 1806478..1807248 - 771 WP_005411960.1 DUF3011 domain-containing protein -
LQ329_RS08435 (LQ329_08435) 1807843..1808250 + 408 WP_005407705.1 hypothetical protein -
LQ329_RS08440 (LQ329_08440) 1808331..1808630 + 300 WP_005407704.1 hypothetical protein -
LQ329_RS08445 (LQ329_08445) 1808888..1809190 - 303 WP_005407703.1 putative addiction module antidote protein Antitoxin
LQ329_RS08450 (LQ329_08450) 1809231..1809536 - 306 WP_005407702.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ329_RS08460 (LQ329_08460) 1809844..1810698 - 855 WP_231347547.1 SPOR domain-containing protein -
LQ329_RS08465 (LQ329_08465) 1810708..1811439 - 732 WP_005407698.1 type III pantothenate kinase -
LQ329_RS08470 (LQ329_08470) 1811436..1812401 - 966 WP_043035430.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
LQ329_RS08475 (LQ329_08475) 1812546..1812824 + 279 WP_005407696.1 hypothetical protein -
LQ329_RS08480 (LQ329_08480) 1812791..1813582 + 792 WP_165931275.1 zinc-dependent peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11444.15 Da        Isoelectric Point: 10.9897

>T226999 WP_005407702.1 NZ_CP088241:c1809536-1809231 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAKEIARALRASNWL

Download         Length: 306 bp

>T226999 NZ_CP122676:c3984009-3983089 [Escherichia coli]
ATGGATCTGCGTGATAGTTATGCCCGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATATAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10703.27 Da        Isoelectric Point: 7.2780

>AT226999 WP_005407703.1 NZ_CP088241:c1809190-1808888 [Stenotrophomonas maltophilia]
MAIKKKVELEAFDVAEHLHTPKEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FSTILKVTRALGVRLHASAA

Download         Length: 303 bp

>AT226999 NZ_CP122676:c3984778-3983996 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAATACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGGCTTACCGTAGATGTAA
CGTCATTGACTACGGAACTAAAAATTGGCGACTGCCAGTTAGCAGGCAGTGTTCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References