Detailed information of TA system TA226998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4377938..4379521
• Replicon: chromosome
• Accession: NZ_CP088240
• Organism: Stenotrophomonas maltophilia strain 2013-SM24

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LQ331_RS20060
• Protein ID: WP_231336678.1
• Coordinates: 4377938..4379260 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LQ331_RS20065
• Protein ID: WP_005407534.1
• Coordinates: 4379264..4379521 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ331_RS20045 (LQ331_20045)	4373337..4374971	-	1635	WP_005407530.1	TldD/PmbA family protein	-
LQ331_RS20050 (LQ331_20050)	4375002..4376633	-	1632	WP_231336677.1	TldD/PmbA family protein	-
LQ331_RS20055 (LQ331_20055)	4377323..4377937	+	615	WP_043034904.1	DUF938 domain-containing protein	-
LQ331_RS20060 (LQ331_20060)	4377938..4379260	-	1323	WP_231336678.1	type II toxin-antitoxin system HipA family toxin	Toxin
LQ331_RS20065 (LQ331_20065)	4379264..4379521	-	258	WP_005407534.1	helix-turn-helix transcriptional regulator	Antitoxin
LQ331_RS20070 (LQ331_20070)	4379683..4383369	-	3687	WP_231336679.1	indolepyruvate ferredoxin oxidoreductase family protein	-
LQ331_RS20075 (LQ331_20075)	4383541..4384176	+	636	WP_088428706.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49027.93 Da
• Isoelectric Point: 6.8179

>T226998 WP_231336678.1 NZ_CP088240:c4379260-4377938 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSTVSEPIFDGLRAAAARLSSMAPEA

Nucleotide

• Length: 1323 bp

>T226998 NZ_CP122676:3780457-3780675 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9584.97 Da
• Isoelectric Point: 11.8468

>AT226998 WP_005407534.1 NZ_CP088240:c4379521-4379264 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Nucleotide

• Length: 258 bp

>AT226998 NZ_CP122676:3780057-3780431 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG