Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1716072..1716869 Replicon chromosome
Accession NZ_CP088229
Organism Enterobacter kobei strain Ek72

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LK774_RS08175 Protein ID WP_176450254.1
Coordinates 1716345..1716869 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A2W0G3H3
Locus tag LK774_RS08170 Protein ID WP_014883303.1
Coordinates 1716072..1716341 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK774_RS08140 (LK774_08150) 1711693..1712193 + 501 WP_014883299.1 DedA family protein -
LK774_RS08145 (LK774_08155) 1712297..1713538 + 1242 WP_023332655.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
LK774_RS08150 (LK774_08160) 1713572..1713799 - 228 WP_014883300.1 YccJ family protein -
LK774_RS08155 (LK774_08165) 1713818..1714414 - 597 WP_014883301.1 NAD(P)H:quinone oxidoreductase -
LK774_RS08160 (LK774_08170) 1714806..1714976 + 171 WP_023332656.1 general stress protein -
LK774_RS08165 (LK774_08175) 1715093..1716010 + 918 WP_023332657.1 DMT family transporter -
LK774_RS08170 (LK774_08180) 1716072..1716341 + 270 WP_014883303.1 DUF1778 domain-containing protein Antitoxin
LK774_RS08175 (LK774_08185) 1716345..1716869 + 525 WP_176450254.1 GNAT family N-acetyltransferase Toxin
LK774_RS08180 (LK774_08190) 1716943..1718265 - 1323 WP_014883305.1 pyrimidine utilization transport protein G -
LK774_RS08185 (LK774_08195) 1718287..1718781 - 495 WP_023332659.1 pyrimidine utilization flavin reductase protein F -
LK774_RS08190 (LK774_08200) 1718791..1719381 - 591 WP_014883307.1 malonic semialdehyde reductase -
LK774_RS08195 (LK774_08205) 1719391..1720191 - 801 WP_023332660.1 pyrimidine utilization protein D -
LK774_RS08200 (LK774_08210) 1720199..1720585 - 387 WP_023332661.1 pyrimidine utilization protein C -
LK774_RS08205 (LK774_08215) 1720597..1721286 - 690 WP_014883310.1 pyrimidine utilization protein B -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(90-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 175 a.a.        Molecular weight: 19689.59 Da        Isoelectric Point: 8.9464

>T226987 WP_176450254.1 NZ_CP088229:1716345-1716869 [Enterobacter kobei]
IVANLTIEMFSEGSDYDFRGFDCGEPSLNAFLTEHLVRQHKGRILRGYLLKDRDHPRVLGYYTLSGSCFEKAMLPSKTQQ
RRIPYVNVPSVTLGRLAVHKDLQGKEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNEQAKRFYLKQGFIPLTGENSHSL
FFPTKSIEQLFEQA

Download         Length: 525 bp

>T226987 NZ_CP122676:1138410-1138721 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10278.72 Da        Isoelectric Point: 5.8836

>AT226987 WP_014883303.1 NZ_CP088229:1716072-1716341 [Enterobacter kobei]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNESSWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT226987 NZ_CP122676:1138718-1139137 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2W0G3H3

References